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Barbara Wyslouzil

Barbara Wyslouzil

Barbara Wyslouzil

Professor of Chemical and Biomolecular Engineering, Professor of Chemistry & Biochemistry



455 CBEC Building
151 W Woodruff Ave
Columbus, OH 43210

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Areas of Expertise

  • Physical


Barbara Wyslouzil is a Professor with a joint appointment between the Departments of Chemical and Biomolecular Engineering and Chemistry. She received her Ph.D. in Chemical Engineering with a minor in Applied Physics from the California Institute of Technology in 1992. Prior arriving at OSU in 2003, she spent 10 years at Worcester Polytechnic Institute and 2 years at Physical Sciences Inc. Her research is in the field of aerosol science. Current research interests center on the formation of new particles from the vapor phase, the internal structure of the multi-component particles, and further transitions within the particles including crystallization and structural transitions. Her group also works on biological and biomedical applications of aerosol science. Professor Wyslouzil has been recognized for her research accomplishments with an NSF Career Award, the WPI Trustees Award for Outstanding Research and Creative Scholarship, and the Kenneth T. Whitby Award for Outstanding Contributions to Aerosol Science and Technology by a Beginning Scientist. 

Research Overview

Aerosols: Formation, Structure, and Further Transitions
Multicomponent nanometer-sized droplets form by vapor condensation in both ambient and industrial environments, and are crucial elements in many health, environmental, and industrial challenges. Accurately predicting the rate at which these phase transitions occur, the structure of the droplets, and determining when and whether further transitions - such as crystallization - may occur, are critical for developing reliable models of industrial processes, climate, and atmospheric chemistry. The nucleation rate directly affects the aerosol size distribution and, thus, the surface area available for heterogeneous reactions. Differences between the surface and interior compositions, in turn, affect heterogeneous chemistry, growth and evaporation kinetics, and even the nucleation rate of the droplets themselves. Finally, the dynamic nature of aerosols suggests that droplets can continue to evolve in structure or phase as the external conditions change.

In our lab we investigate aerosol processes by making high number density aerosols in a supersonic nozzle and probing the properties of the flowing gas mixture and the aerosol itself  a broad array of analytical techniques including static pressure measurements, small angle neutron scattering (SANS), small angle X-ray scattering (SAXS) and infra-red absorption spectroscopy experiments. From these detailed measurements we are able to extract vapor - liquid or liquid - crystal nucleation rates and directly test our understanding of how material should partition inside droplets. Current systems of interest include compounds that exhibit strong vapor phase association as well as co-condensation in highly immiscible systems.

Photograph shows the  supersonic nozzle setup in the SAXS at the 12ID experimental station at Argonne National Laboratory.


Wyslouzil figure 1

Barbara Wyslouzil will be accepting new graduate students, undergraduate students or postdoctoral researcher into her group, and welcomes inquiries regarding openings.

Recent Publications

1. Shinobu Tanimura, Gerald Wilemski, and Barbara E. Wyslouzil, "CH3CH2OD/D2O Binary Condensation in a Supersonic Laval Nozzle: Presence of small clusters inferred from a macroscopic energy balance," J. Chem. Phys., 132, 144301 (2010).

2. Somnath Sinha, Ashutosh Bhabhe, Hartawan Laksmono, Judith Wölk, Reinhard Strey, and Barbara Wyslouzil, "Argon nucleation in a cryogenic supersonic nozzle," J. Chem. Phys., 132, 064304 (2010).

3. David Ghosh, Dirk Bergmann, Regina Schwering, Judith Wölk, Reinhard Strey, Shinobu Tanimura, Barbara E. Wyslouzil, "Homogeneous nucleation of a homologous series of n-alkanes (CiH2i+2, i=7-10) in a supersonic nozzle," J. Chem. Phys., 132, 024307 (2010).

4. Yun Wu, Zhengzheng Fei, L. James Lee, Barbara E. Wyslouzil, "Coaxial Electrohydrodynamic Spraying of Plasmid DNA/Polyethylenimine (PEI) for Nonviral Gene Delivery" Biotechnology and Bioengineering, 105, 834 - 841, (2010).

5. Yun Wu, Bo Yu, Andrew Jackson, Weibin Zha, L. James Lee, Barbara E. Wyslouzil "Electrohydrodynamic Spraying: A novel one-step technique to prepare oligodeoxynucleotide (ODN) encapsulated lipoplex nanoparticles" Molecular Pharmaceutics, 6, 1371-1379 (2009)

6. Y. Wu, J. Chalmers, B. E. Wyslouzil, "The use of electrospray to disperse hydrophobic compounds in aqueous media," Aerosol Science and Technology, 43, 902-910 (2009)

7. Somnath Sinha, Barbara E. Wyslouzil, and Gerald Wilemski, "Modeling of H2O/D2O Condensation in Supersonic Nozzles", Aerosol Sci. Technol., 43:9-24, (2009)

8. Somnath Sinha, Hartawan Laksmono, and Barbara E. Wyslouzil, "A cryogenic supersonic nozzle apparatus to study homogeneous nucleation of Ar and other simple molecules," Rev. Sci. Instrum. 79, 114101, (2008).

9. Lisa L. Van Loon, Heather C. Allen, and Barbara E. Wyslouzil, "Effective diffusion coefficients for methanol in sulfuric acid solutions measured by Raman spectroscopy", J. Phys. Chem. A, 112, 10758-10763 (2008).

10. David Ghosh, Alexandra Manka, Reinhard Strey, Soenke Seifert, Randall E. Winans, and Barbara E. Wyslouzil, "Using small angle x-ray scattering to measure the homogeneous nucleation rates of n‑propanol, n‑butanol, and n‑pentanol in supersonic nozzle expansions", J. Chem. Phys., 129(2008).

11. Pamela Weathers, Chunzhao Liu, Melissa Towler, and Barbara Wyslouzil, "Mist reactors: principles, comparison of various systems, case studies", Electronic Journal of Integrative Biosciences, Special Issue on Hairy Roots  (2008)

12. Barbara Wyslouzil, Gerald Wilemski, Reinhard Strey, Soenke Seifert, and Randall E. Winans, "Small angle x-ray scattering measurements probe water droplet evolution under highly non-equilibrium conditions", Phys. Chem. Chem. Phys., 9, 5353-5358, (2007).

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