Tsai Laboratory
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Tsai Laboratory |
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List of Publications:
| [1981-1990] | [1991-2000] |
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1. "Terpenes and Sterols of Cunninghamia Konishii," Y. S. Cheng and M.-D. Tsai, Phytochemistry, 11, 2108-2109 (1972).
2. "Air Oxidation of a-Terpineol," M.-D. Tsai and Y. S. Cheng, J. Chinese Chem. Soc., 22, 149-155 (1974).
3. "Dye-sensitized Photooxidation of a-Terpineol," Y. S. Cheng, M.-D. Tsai, J. M. Fang and S. S. Hsu, Chemistry (The Chinese Chem. Soc., Taiwan, China), 8-11 (1975).
4. "Conformational Analysis of Pyridoxal Amino Acid Schiff's Bases," H. J. R. Weintraub, M.-D. Tsai, S. R. Byrn, C.-j. Chang and H. G. Floss, Int. J. Quantum Chem., QBS 3, 99-105 (1976).
5. "Conformational Analysis of Pyridoxal Schiff's Bases," M.-D. Tsai, S. R. Byrn, C.-j. Chang, H. G. Floss and H. J. R. Weintraub, Biochemistry 17, 3177-3182 (1978).
6. "Conformation-Reactivity Relationship for Pyridoxal Schiff's Bases,"M.-D. Tsai, H. J. R. Weintraub, S. R. Byrn, C.-j. Chang and H. G. Floss, Biochemistry, 17, 3183-3188 (1978).
7. "Stereochemistry and Mechanism of Reactions Catalyzed by Tryptophan Synthetase and its b2 Subunit, M.-D. Tsai, E. Schleicher, R. Potts, G. E. Skye and H. G. Floss, J. Biol. Chem., 253, 5344-5349 (1978).
8. "Stereochemistry and Mechanism of Reactions Catalyzed by Tryptophanase from Escherichia coli, J. C. Vederas, E. Schleicher, M.-D. Tsai and H. G. Floss, J. Biol. Chem., 253, 5350-5354 (1978).
9. "Stereochemistry of the b-Cyanoalanine Synthetase and S-Alkylcysteine Lyase Reactions," M.-D. Tsai, J. Weaver, H. G. Floss, E. E. Conn, R. K. Creveling and M. Mazelis, Arch. Biochem. Biophys., 190, 553-559 (1978).
10. "Stereochemistry of Enzymatic Transmethylation," H. G. Floss, L. Mascaro, M.-D. Tsai and R. W. Woodard, in Transmethylation (E. Usin, R. T. Borchardt and C. R. Creveling, Eds.), Elsevier North-Holland, New York (1979), pp. 135-141.
11. "Chiral Methyl Groups," H. G. Floss and M.-D. Tsai, Adv. Enzymol. 50, 243-302 (1979).
12. "Stereochemistry and Mechanism of Reactions Catalyzed by Indolyl 3-alkane-a-Hydroxylase," M.-D. Tsai, H. G. Floss, H. J. Rosenfeld and J. Roberts, J. Biol. Chem., 254, 6437-6443 (1979).
13. "Stereochemical Course of the Transmethylation Catalyzed by Catechol O-Methyltransferase," R. W. Woodard, M.-D. Tsai, H. G. Floss, P. A. Cook and J. K. Coward, J. Biol. Chem., 255, 9124-9127 (1980).
14. "First Observation of Amino Acid Side Chain Dynamics in Membrane Proteins Using High Field Deuterium NMR Spectroscopy," R. A. Kinsey, A. Kintanar, M.-D. Tsai, R. L. Smith, N. Janes and E. Oldfield, J. Biol. Chem., 256, 4146-4149 (1981).
15. "Protein Crystals, Membrane Proteins and Membrane Lipids." E. Oldfield, N. James, R. Kinsey, A. Kintanar, R. W. K. Lee, T. M. Rotngeb, S. Schramm, R. Skarjune, R. Smith and M.-D. Tsai, Biochem. Soc. Trans., 45, 155-181 (1981).
16. "Use of 31P Nuclear Magnetic Resonance to Distinguish Bridge and Non-bridge Oxygens of 17O-enriched Nucleoside Triphosphates. Stereochemistry of Acetate Activation by Acetyl CoA Synthetase," M.-D. Tsai, Biochemistry 18, 1468-1472 (1979).
17. "Applicability of the 31P(17O) NMR Method in the Study of Enzyme Mechanism Involving Phosphorus," M.-D. Tsai, S. L. Huang, J. F. Kozlowski and C. C. Chang, Biochemistry 19, 3531-3536 (1980).
18. "Chirality at a Pro-pro-prochiral Phosphorus Center, Stereochemical Course of the 5'-Nucleotidase-Catalyzed Reaction," M.-D. Tsai and T. T. Chang, J. Am. Chem. Soc., 102, 5416-5418 (1980).
19. "Stereochemistry of the Hydrolysis of Adenosine 5'-Thiophosphate Catalyzed by Venom 5'-Nucleotidase," M.-D. Tsai, Biochemistry 19, 5310-5316 (1980).
20. "Does Mg2+ Interact with the a-Phosphate of ATP? An Investigation by 17O NMR," S.-L. Huang and M.-D. Tsai, Biochemistry 21, 951-959 (1982).
21. "Use of 31P(18O), 31P(17O), and 17O NMR Methods to Study Enzyme Mechanism Involving Phosphorus," M.-D. Tsai, Methods Enzymol. 87, 235-279 (1982).
22. "Phospholioids Chiral at Phosphorus. 1. Stereochemistry of Transphosphatidylation Catalyzed by Phospholipase D," K. Bruzik and M.-D. Tsai, J. Am. Chem. Soc. 104, 863-865 (1982).
23. "Phospholipids Chiral at Phosphorus. 2. Preparation, Property and Application of Chiral Thiophospholipids" K. Bruzik, S. M. Gupte and M.-D. Tsai, J. Am. Chem. Soc. 104, 4682-4684 (1982).
24. "Phospholipids Chiral at Phosphorus. 3. Preparation and Spectral Properties of Chiral Thiophospholipids," K. Bruzik, R.-T. Jiang and M.-D. Tsai, Biochemistry 22, 2478-2486 (1983).
25. "Phospholipids Chiral at Phosphorus. 4. Could Membranes be Chiral at Phosphorus?" M.-D. Tsai, R.-T. Jiang and K. Bruzik, J. Am. Chem. Soc. 105, 2478-2480 (1983)
26. "Phospholipids Chiral at Phosphorus. Synthesis, Absolute Configurations and Applications." K. Bruzik, R.-T. Jiang and M.-D. Tsai, Phosphorus and Sulfur 18, 369-372 (1983).
27. "Effects of 17O and 18O on 31P NMR: Further Investigation and Applications," R. D. Sammons, P. A. Frey, K. Bruzik and M.-D. Tsai, J. Am. Chem. Soc. 105, 5455-5461 (1983).
28. "NMR Methods Involving Oxygen Isotopes in Biophosphates," M.-D. Tsai and K. Bruzik, in Biological Magnetic Resonance, Vol. 5, L. J. Berliner and J. Reuben, Eds., Plenum Press, New York, pp. 129-181 (1983).
29. "Phospholipids Chiral at Phosphorus. 5. Synthesis and Configurational Analysis of Chiral [17O,18O]-Phosphatidylethano1amine." K. Bruzik and M.-D. Tsai, J. Am. Chem. Soc. 106, 747-754 (1984).
30. "Phospholipids Chiral at Phosphorus. 6. Synthesis of Chiral Phosphatidylcholine and Stereochemistry of Phospholipase D." K. Bruzik and M.-D. Tsai, Biochemistry 23, 1656-1661 (1984).
31. "Phospholipids Chiral at Phosphorus. 7. Absolute Configuration of Chiral Thiophospholipids and Stereochemistry of Phospholipase D." R.-T. Jiang, Y.-J. Shyy, and M.-D. Tsai, Biochemistry 23, 1661-1667 (1984).
32. "Phospholipids Chiral at Phosphorus. 8. Properties of Small Unilamellar Vesicles of Chiral Thiophosphatidylcholine." T.-C. Tsai, R.-T. Jiang and M.-D. Tsai, Biochemistry 23, 5564-5570 (1984).
33. "Stereochemistry of Biological Reactions at Pro-prochiral Centers." H. G. Floss, M.-D. Tsai, and R. W. Woodard, Topics in Stereochemistry, E. L. Eliel, N. L. Allinger and S. H. Wilen, Eds., John Wiley & Sons, pp. 253-321 (1984).
34. "Use of Chiral thiophosphates and the Stereochemistry of Enzymatic Phosphoryl Transfer." M.-D. Tsai, in 31P NMR: Principles and Applications, D. Gorenstein. Ed.. Academic Press, pp. 175-197 (1984).
35. "Phospholipids Chiral at Phosphorus. 9. Use of Chiral Thiophosphatidylcholine to Study the Metal-Binding Properties of Bee Venom Phospholipase A2,"T.-C. Tsai, J. Hart, R.-T. Jiang, K. Bruzik and M.-D. Tsai, Biochemistry 24, 3180-3188 (1985).
36. "Metal-Nucleotide Interactions. 3. 17O, 31P and 1H NMR Studies on the Interactions of Sc(III) and La(III) with ATP," Y.-J. Shyy, T.-C. Tsai and M.-D. Tsai, J. Am. Chem. Soc. 107, 3478-3484 (1985).
37. "Mechanism of Adenylate Kinase. 1. Use of 17O NMR to Study the Binding Properties of Substrates," D. A. Wisner, C. Steginsky, Y.-J. Shyy and M.-D. Tsai, J. Am. Chem. Soc. 107, 2814-2815 (1985).
38. "Phospholipids Chiral at Phosphorus. 10. Use of Chiral Thiophospholipids to Study the Mechanism of Phospholipase A2," M.-D. Tsai, K. Bruzik, J. Hart, R.-T. Jiang, T. Rosario-Jansen, T.-C. Tsai and D. A. Wisner, in "Mechanisms of Enzymatic Reactions: Stereochemistry", P. A. Frey, ed., Elsevier, 115-126 (1986).
39. "Phospholipids Chiral at Phosphorus. 11. FT-IR Study on the Gel-Liquid Crystalline Transition of Chiral Thiophosphatidylcholine," S.-B. Chang, J. O. Alben, D. A. Wisner and M.-D. Tsai, Biochemistry 25, 3435-3440 (1986).
40. "Phospholipids Chiral at Phosphorus. 12. Configurational Effect on the Thermotropic Properties of Chiral Dipalmitoylthiophosphatidylcholine," D. A. Wisner, T. Rosario-Jansen and M.-D. Tsai, J. Am. Chem. Soc., 108, 8064-8068 (1986).
41. "Phospholipids Chiral at Phosphorus. 13. Stereochemical Comparison of Phospholipase A2, Lecithin-Cholesterol Acyl Transferase, and Platelet-Activating Factor," T. Rosario-Jansen, H. J. Pownall, J. P. Noel and M.-D. Tsai, Phosphorus and Sulfur 30, 601-604 (1987).
42. Phospholipids Chiral at Phosphorus. 14. Stereochemical Effects on the Thermotropic Properties of Thiophosphatidylcholines and Thiosphingomyelins,"M.-D. Tsai, K. S. Bruzik, D. Wisner and S.-H. Liu, in"Biophosphates and Their Analogues, Synthesis, Structure, Metabolism and Activity", K.S. Bruzik and W.J. Stec, Eds., Elsevier, pp. 561-570 (1987).
43. "Is the Binding of Mg2+ to Calmodulin Significant? An Investigation by 25Mg NMR," M.-D. Tsai, T. Drakenberg, E. Thulin and S. Forsen, Biochemistry, 26, 3635-3643 (1987).
44. "Magnesium Binding to Calcium-Binding Proteins: A Regulatory Function?" T. Drakenberg, S. Forsen, E. Thulin, and M.-D. Tsai, in Calcium-Binding Proteins in Health and Disease, Norman, A. W., Vanaman, T. C., and Means, A. R., Eds., Academic Press, pp. 430-432 (1987).
45. "Phospholipids Chiral at Phosphorus. 15. Steric Course of Phosphatidylserine Synthases from E. coli and Yeast," C. R. H. Raetz, G. M. Carman, W. Dowhan, R.-T. Jiang, W. Waszkuc, W. Loffredo and M.-D. Tsai, Biochemistry, 26 4022-4027 (1987).
46. "A Calorimetric Study of the Thermotropic Behavior of Pure Sphingomyelin Diastereomers," K. S. Bruzik and M.-D. Tsai, Biochemistry 26, 5364-5368 (1987).
47. "Mechanism of Adenylate Kinase. 2. Does ATP bind to the AMP Site?" Y. J. Shyy, G. Tian, and M.-D. Tsai, Biochemistry, 26, 6411-6415 (1987).
48. "Mechanism of Adenylate Kinase. 3. Use of Deuterium NMR to Show Lack of Correlation Between Local Substrate Dynamics and Local Binding Energy." C. R. Sanders II and M.-D. Tsai, J. Am. Chem. Soc. 110, 3323-3324 (1988).
49. "Steric Course of the Reaction Catalyzes by Phosphatidylserine Decarboxylase from E. coli". Z. No, C. R. Sanders II, W. Dowhan, and M.-D. Tsai, Bioorg. Chem., 16, 184-188 (1988).
50. "Phospholipids Chiral at Phosphorus. 16. Synthesis and Stereospecificity of Phosphorothioate Analogues of Platelet Activating Factor." T. Rosario-Jansen, R.-T. Jiang, D. J. Hanahan, and M.-D. Tsai, Biochemistry, 27, 4619-4624 (1988).
51. "Phospholipids Chiral at Phosphorus. 17. Characterization of the Subgel Phase of Thiophosphatidylcholines by Use of X-Ray Diffraction, P-31 NMR, and FT-IR". H. E. Sarvis, W. Loffredo, R. A. Dluhy, L. Hernqvist, D. A. Wisner, and M.-D. Tsai, Biochemistry, 27, 4625-4631 (1988).
52. "Mechanism of Adenylate Kinase. 4. Histidine-36 Is Not Directly Involved in Catalysis, But Protects Cysteine-25 and Stabilizes the Tertiary Structure." G. Tian, C. R. Sanders II, F. Kishi, A. Nakazawa, and M.-D. Tsai, Biochemistry, 27, 5544-5552 (1988).
53. "Use of Short-Chain Cyclopentano-phosphatidylcholines to Probe the Mode of Activation of Phospnolipase A2 from Bovine Pancreas and Bee Venom". G. L. Lin, J. Noel, W. Loffredo, H. Sable, and M.-D. Tsai, J. Biol. Chem., 263, 13208-13214 (1988).
54. "Phospholipase A2 Engineering: Design, Synthesis, and Expression of a Gene for Bovine Pancreatic Phospholipase A2". J. P. Noel and M.-D. Tsai, J. Cellular Biochem. 40 (UCLA Symposium Series), 309-320 (1989).
55. "Phospholipids Chiral at Phosphorus. 18. Stereochemistry of Phosphatidylinositide-specific Phospholipase C". G. Lin and M.-D. Tsai, J. Am. Chem. Soc., 111, 3099-3101 (1989).
56. "Ligand-Protein Interactions Via NMR of Quadrupolar Nuclei". C. R. Sanders II and M.-D. Tsai, Methods. Enzymol. 177, 317-333 (1989).
57. "Mechanism of Adenylate Kinase. 5. Is There a Relationship Between Local Substrate Dynamics, Local Binding Energy, and the Catalytic Mechanism?" C. R. Sanders II, G. Tian and M.-D. Tsai, Biochemistry 28, 9028-9043 (1989).
58. "Phospholipids Chiral at Phosphorus. 19. Synthesis and Configurational Assignment of Phosphorothioate Analogues of Phosphatidylserine". W. M. Loffredo and M.-D. Tsai, Bioorg. Chem. 18, 78-84 (1990).
59. "Phospholipids Chiral at Phosphorus. 20. Stereochemical Mechanism of the Reactions Catalyzed by Phosphatidylinositide-Specific Phospholipase C From Bacillus Cereus and Guinea Pig Uterus". G. H. Lin, C. F. Bennett, and M.-D. Tsai, Biochemistry 29, 2747-2757 (1990).
60. "Mechanism of Adenylate Kinase. 6. Are the Essential Lysines Essential?" G. Tian, H. Yan, R.-T. Jiang, F. Kishi, A. Nakazawa, and M.-D. Tsai, Biochemistry 29, 4296-4304 (1990).
61. "Phospholipids Chiral at Phosphorus. 22. Synthesis of Chiral Dioleoylthiophosphatidylcholine and Stereospecificity of Lecithin-Cholesterol Acyltransferase". T. Rosario-Jansen, H. Pownall, R.-T. Jiang, and M.-D. Tsai, Bioorg. Chem. 18, 179-184 (1990).
62. "A Novel Expression Vector for High-Level Synthesis and Secretion of Foreign Proteins in E. coli: Overproduction of Bovine Pancreatic Phospholipase A2." T. Deng, J. P. Noel, and M.-D. Tsai, Gene 93, 229-234 (1990).
63. "Phospholipase A2 Engineering. 3. Replacement of Lysine-56 by Neutral Residues Improves Catalytic Efficiency Significantly, Alters Substrate Specificity, and Clarifies the Mechanism of Interfacial Recognition". J. P. Noel, T. Deng, K. J. Kelly, and M.-D. Tsai, J. Am. Chem. Soc. 112, 3704-3706 (1990).
64. "Mechanism of Adenylate Kinase. 7. Structural and Functional Demonstration of Arginine-138 as a Key Catalytic Residue Which Cannot be Replaced by Lysine". H. Yan, Z. Shi, and M.-D. Tsai, Biochemistry 29, 6385-6392 (1990).
65. "Phospholipase A2 Engineering. 4. Can the Active Site Aspartate Function Alone?" C. M. Dupureur, T. Deng, J.-G. Kwak, J. Noel, and M.-D. Tsai, J. Am. Chem. Soc. 112, 7074-7076 (1990).
66. "Phospholipids Chiral at Phosphorus. 23. Dramatic Effect of P-Chirality on the Deuterium NMR Properties of the Choline Head Group of Phospholipids in the Liquid Crystalline Phase". W. M. Loffredo, R.-T. Jiang, and M.-D. Tsai, Biochemistry 29, 10912-10918 (1990).
67. "Mechanism of Adenylate Kinase. 8. Critical Evaluation of the X-Ray Model and Assignment of the AMP Site." H. Yan, T. Dahnke, B. Zhou, A. Nakazawa, and M.-D. Tsai, Biochemistry 29, 10956-10964 (1990).
68. "Phospholipids Chiral at Phosphorus. 21. Phospholipase Stereospecificity at Phosphorus." K. Bruzik and M.-D. Tsai, Methods Enzymol. 197, 258-269 (1991).
69. "Phospholipids Chiral at Phosphorus. 24. Phosphorothioate Analogs of Phosphatidylinositol and Inositol 1,2-Cyclic Phosphate: Applications to the Mechanism of Phospholipase C." K. Bruzik, G. Lin, and M.-D. Tsai, ACS Symp. Series 463, 172-185 (1991).
70. "Mechanism of Adenylate Kinase. 9. Demonstration of Functional Relationship Between Aspartate-93 and Mg2+ by Site-Directed Mutagenesis and 1H, 31P, and 25Mg NMR." H. Yan and M.-D. Tsai, Biochemistry 30, 5539-5546 (1991).
71. "Mechanism of Adenylate Kinase. 10. Reversing Phosphorus Stereospecificity of an Enzyme by Site-Directed Mutagenesis". R.-T. Jiang, T. Dahnke, and M.-D. Tsai, J. Am. Chem. Soc. 113, 5485-5486 (1991).
72. "Mechanism of Adenylate Kinase. 11. Site-Directed Mutagenesis Versus X-Ray and NMR." M.-D. Tsai and H. Yan, Biochemistry 30, 6806-6818 (1991). [This is a Perspectives in Biochemistry article.]
73. "Phospholipase A2 Engineering. 5. X-Ray Structural and Functional Evidence for the Interaction of Lysine-56 with Substrates." J. P. Noel, C. A. Bingman, T. Deng, C. M. Dupureur, K. J. Hamilton, R.-T. Jiang, J.-G. Kwak, C. Sekharudu, M. Sundaralingam, and M.-D. Tsai, Biochemistry 30, 11801-11811 (1991).
74. "Mechanism of Adenylate Kinase. 12. Prediction and Demonstration of Enhancement of Phosphorus Stereospecificity by Site-Directed Mutagenesis". T. Dahnke, R.-T. Jiang, and M.-D. Tsai, J. Am. Chem. Soc. 113, 9388-9389 (1991).
75. "Practical Synthesis of Enantiomerically Pure myo-Inositol Derivatives." K. S. Bruzik, J. Myers, and M.-D. Tsai, Tetrahedron Lett., 1009-1012 (1992).
76. "Phospholipase A2 Engineering. 6. Single Amino Acid Substitutions of Active Site Residues Convert the Rigid Enzyme to Highly Flexible Conformational States." C. M. Dupureur, Y. Li, and M.-D. Tsai, J. Am. Chem. Soc. 114, 2748-2749 (1992).
77. "Phospholipids Chiral at Phosphorus. 25. Stereochemical Mechanism for the Formation of Inositol 1-Phosphate Catalyzed by Phosphatidylinositide-Specific Phospholipase C." K. S. Bruzik, A. M. Morocho, D.-Y. Jhon, S. G. Rhee, and M.-D. Tsai, Biochemistry 31, 5183-5193 (1992).
78. "Mechanism of Adenylate Kinase. 13. Structural and Functional Roles of Arginine-97 and Arginine-132." T. Dahnke, Z. Shi, H. Yan, R.-T. Jiang, and M.-D. Tsai, Biochemistry 31, 6318-6328 (1992).
79. "Phospholipase A2 Engineering. 7. Structural and Functional Roles of Highly Conserved Tyrosine-52 and Tyrosine-73." C. M. Dupureur, B.-Z. Yu, M. Jain, J. P. Noel, T. Deng, Y. Li, I.-J. Byeon, and M.-D. Tsai, Biochemistry 31, 6402-6413 (1992).
80. "Efficient and Systematic Syntheses of Enantiomerically Pure and Regiospecifically Protected Myo-Inositols." K. S. Bruzik and M.-D. Tsai, J. Am. Chem. Soc. 114, 6361-6374 (1992).
81. "Interfacial Catalysis by Phospholipase A2: The Rate-Limiting Step for Maximal Turnover". M. K. Jain, B.-Z. Yu, J. Rogers, M. H. Gelb, M.-D. Tsai, E. K. Hendrickson, and H. S. Hendrickson, Biochemistry 31, 7841-7847 (1992).
82. "Phospholipase A2 Engineering. 9. The Structural and Functional Roles of Aromaticity and Hydrophobicity in the Conserved Phenylalanine-22 and Phenylalanine-106 Aromatic Sandwich." C. M. Dupureur, B.-Z. Yu, J. A. Mamone, M. K. Jain, and M.-D. Tsai, Biochemistry 31, 10576-10583 (1992).
83. "Crystal Structure of the Phospholipase A2 Double Mutant (Y52F,Y73F): Hydrophobic Interactions Compensate the Disrupted Hydrogen Bonds in the Stabilization of the Catalytic Network." C. Sekharudu, B. Ramakrishnan, B. Huang, R.-T. Jiang, C. M. Dupureur, M.-D. Tsai, and M. Sundaralingam, Protein Science 1, 1585-1594 (1992).
84. "Modification of a Bruker AM-600 Spectrometer for Double and Triple Resonance Three Dimensional and Four Dimensional Experiments Illustrated with Chicken Adenylate Kinase Resonance Assignments." E. S. Mooberry, A. S. Edison, F. Abildgaard, J. L. Markley, I.-J. L. Byeon, and M.-D. Tsai, Proceedings of the International Symposium on Spectroscopy and Structure of Molecules and Nuclei, N. R. Johnson, W. N. Shelton, and M. El-Sayed, Eds., World Scientific, pp. 375-380 (1992).
85. "Mechanism of Adenylate Kinase. 14. What Can be Learned from a Mutant with Minor Perturbation in Kinetic Parameters?" Z.-T. Shi, I.-J. L. Byeon, R.-T. Jiang, ande M.-D. Tsai, Biochemistry 32, 6450-6458 (1993).
86. "Phospholipase A2 Engineering. 10. The Aspartate...Histidine Catalytic Diad Also Plays an Important Structural Role." Y. Li and M.-D. Tsai, J. Am. Chem. Soc. 115, 8523-8526 (1993).
87. "Mechanism of Adenylate Kinase. 15. 1H, 13C, and 15N NMR Assignments, Secondary Structures, and Substrate Binding Sites." I.-J. L. Byeon, H. Yan, A. S. Edison, E. S. Mooberry, F. Abildgaard, J. L. Markley, and M.-D. Tsai, Biochemistry 32, 12508-12521 (1993).
88. "Mechanism of Adenylate Kinase. 16. The Conserved Aspartates 140 and 141 Are Important for Transition State Stabilization Instead of Substrate-Induced Conformational Changes." T. Dahnke and M.-D. Tsai, J. Biol. Chem. 269, 8075-8081 (1994).
89. "Toward the Mechanism of Phospohatidylinositide-Specific Phospholipase C." K. S. Bruzik and M.-D. Tsai, Bioorg. & Med. Chem. 2, 49-72 (1994).
90. "Are D- and L-chiro-Phosphoinositides Substrates of Phosphatidylinositol-Specific Phospholipase C?" K. S. Bruzik, A. A. Hakeem, and M.-D. Tsai, Biochemistry 33, 8367-8374 (1994).
91. "A Small, High Copy Number Vector Suitable for Both in vitro and in vivo Gene Expressions." B. Huang, Z. Shi, and M.-D. Tsai, Gene 151, 143-145 (1994).
92. "Structure and Function of the Catalytic Site Mutant Asp 99 Asn of Phospholipase A2: Absence of the Conserved Structural Water." A. Kumar, C. Sekharudu, B. Ramakrishnan, C. M. Dupureur, H. Zhu, M.-D. Tsai, and M. Sundaralingam, Protein Science 3, 2082-2088 (1994).
93. "Phospholipase A2 Engineering. 12. Structural and Functional Roles of the Highly Conserved Active Site Residue Aspartate-49." Y. Li, B.-Z. Yu, H. Zhu, M. K. Jain, and M.-D. Tsai, Biochemistry 33, 14714-14722 (1994).
94. "Phospholipase A2 Engineering. 13. Conversion of Bovine Pancreatic Phospholipase A2 into a Competitor of Neurotoxic Phospholipase A2 by Site-Directed Mutagenesis at a Single Site." M.-C. Tzeng, C.-H. Yen, M.-J. Hseu, C. M. Dupureur, and M.-D. Tsai, J. Biol. Chem. 270, 2120-2123 (1995).
95. "Mechanism of Adenylate Kinase. 17. Manipulating the Phosphorus Stereospecificity of Adenylate Kinase by Site-Directed Mutagenesis." M.-D. Tsai, R.-T. Jiang, T. Dahnke, and Z. Shi, Methods Enzymol. 249, 425-443 (1995).
96. "Mechanism of Adenylate Kinase. 18. The Essential Lysine Helps Orient the Phosphates and the Active Site Residues to Proper Conformations." I.-J. L. Byeon, Z. Shi, and M.-D. Tsai, Biochemistry 34, 3172-3182 (1995).
97. "Phospholipase A2 Engineering. 14. Probing the Structural and Functional Roles of N-Terminal Residues with Site-Directed Mutagenesis." X. Liu, H. Zhu, B. Huang, J. Rogers, B.-Z. Yu, A. Kumar, M. K. Jain, M. Sundaralingam, and M.-D. Tsai, Biochemistry 34, 7322-7334 (1995).
98. "Immunogenicity and Conformational Properties of an N-linked Glycosylated Peptide Epitope of Human T-Lymphotropic Virus Type 1 (HTLV-1)." S. F. Conrad, I.-J. L Byeon, A. M. DiGeorge, M. D. Lairmore, M.-D. Tsai, and P. T. P. Kaumaya, Biomedical Peptides, Proteins, & Nucleic Acids 1, 83-92 (1995).
99. "Binding-Proteins on Synaptic-Membranes for Crotoxin and Taipoxin, 2 Phospholipases A2 with Neurotoxicity." M. C. Tzeng, C. H. Yen, M. J. Hseu, C. C. Tseng, M.-D. Tsai, and C. M. Dupureur, Toxicon 33, 451-457 (1995).
100. "Phospholipase A2 Engineering. 15. The Roles of Disulfide Bonds in Structure, Conformational Stability, and Catalytic Function.'' H. Zhu, C. M. Dupureur, X. Zhang, and M.-D. Tsai, Biochemistry 34, 15307-15314 (1995).
101. "Design, Synthesis and Biochemical Applications of Analogs of Phosphatidylinositol", N. K. Bhamare, Y. Wang, M.-D. Tsai, K. S. Bruzik, Phosphorus, Sulfur, and Silicon 109-110, 317-320 (1996).
102. "Structure-Function Relationship of Adenylate Kinase. 19. Glutamine-101 in AMP Specificity." S. Beichner, I.-J. L. Byeon, and M.-D. Tsai, PEPTIDES: Chemistry, Structure, and Biology, Kaumaya, P. T. P. and Hodges, R. S. (Eds.), Mayflower Scientific Ltd. (1996), Chapter 303, pp. 721-723.
103. "DNA Polymerase b: 1. Pre-Steady-State Kinetic Analysis and the Roles of Arginine-283 in Catalysis and Fidelity." B. G. Werneburg, J. Ahn, X. Zhong, R. J. Hondal, V. Kraynov, and M.-D. Tsai, Biochemistry 35, 7041-7050 (1996).
104. "Mechanism of Adenylate Kinase. 20. Probing the Importance of the Aromaticity in Tyrosine-95 and the Ring Size in Proline-17 with Unnatural Amino Acids." Z. Zhao, X. Liu, Z. Shi, L. Danley, B. Huang, R.-T. Jiang, and M.-D. Tsai, J. Am. Chem. Soc. 118, 3535-3536 (1996).
105. "Tumor Suppressor p16INK4A: 1. Structural Characterization of Wild-type and Mutant Proteins by NMR and Circular Dichroism." A. Tevelev, I.-J. L. Byeon, T. Selby, K. Ericson, H.-J. Kim, V. Kraynov, and M.-D. Tsai, Biochemistry 35, 9475-9487 (1996).
106. "Splase: A New Class IIs Zinc Finger Restriction Enzyme with Specificity for Sp1 Binding Sites." B. Huang, C. J. Schaeffer, and M.-D. Tsai, J. Protein Chem. 15, 481-489 (1996).
107. "Synthesis of Inositol Phosphodiesters by Phospholipase C-Catalyzed Transesterification". K. S. Bruzik, Z. Guan, S. Riddle, and M.-D. Tsai, J. Am. Chem. Soc. 118, 7679-7688 (1996).
108. "Phospholipase A2 Engineering. 16. Deletion of the C-Terminus Segment Changes Substrate Specificity and Uncouples Calcium and Substrate Binding at the Zwitterionic Interface." B. Huang, B.-Z. Yu, J. Rogers, K. Sekar, M. Sundaralingam, M.-D. Tsai, and M. K. Jain, Biochemistry 35, 12164-12174 (1996).
109. "Binding Proteins on Synaptic Membranes for Certain Phospholipases A2 with Presynaptic Toxicity". M.-C. Tzeng, C.-H. Yen, and M.-D. Tsai, in "Natural Toxins II", pp. 271-278, B. R. Singh and A. T. Tu, Eds., Plenum Press, New York (1996). [Also cited as Adv. Exp. Med. Biol. 391, 271-8 (1996).]
110. "Splase: The Design of a New Restriction Enzyme with Specificity for Sp1 Binding Sites." B. Huang, C. J. Schaeffer, and M.-D. Tsai, in Perspectives on Protein Engineering 3 (Geisow, M. J., ed), BIODIGM, Nottingham (1996).
111. "Effects of Glycosylation of a Peptide Epitope from HTLV-1 gp46 on Structure and Immunogenicity." S. F. Conrad, I.-J. L Byeon, A. M. DiGeorge, M. D. Lairmore, M.-D. Tsai, and P. T. P. Kaumaya, Pept.: Chem., Struct. Biol., Proc. Am. Pept. Symp., 14th, 448-9 (1996).
112. "DNA Polymerase b: 2. Structure-Fidelity Relationship from Pre-Steady-State Kinetic Analysis of All Possible Correct and Incorrect Base Pairs for Wild Type and R283A Mutant." J. Ahn, B. G. Werneburg, and M.-D. Tsai, Biochemistry 36, 1100-1107 (1997).
113. "DNA Polymerase b: 3. Analysis of the contribution of Tyrosine-271 and Asparagine-279 to Substrate Specificity and Fidelity of DNA Replication by Pre-steady-state Kinetics." V. S. Kraynov, B. G. Werneburg, X. Zhong, H. Lee, J. Ahn, and M.-D. Tsai, Biochem. J. 323, 103-111 (1997).
114. "Phospholipase A2 Engineering. 17. Structural and Functional Roles of the Highly Conserved Active Site Residue Aspartate-99." K. Sekar, B.-Z. Yu, J. Rogers, J. Lutton, X. Liu, X. Chen, M.-D. Tsai, M. Jain, & M. Sundaralingam, Biochemistry 36, 3104-3114 (1997).
115. "Synthesis of Enantiomerically Pure Phosphorothiolate Assay Substrate for Phosphatidylinositol-Specific Phospholipase C." Cornelia Mihai, Jan Mataka, Suzette Riddle, Ming-Daw Tsai, and Karol S. Bruzik, Bioorg. Med. Lett. 7, 1235-1238 (1997).
116. "Mechanism of PI-Specific Phospholipase C. 1. Kinetic and Stereochemical Evidence for an Interaction between Arginine-69 and the Phosphate Group of Phosphatidylinositol." Robert J. Hondal, Suzette R. Riddle, Alexander V. Kravchuk, Zhong Zhao, Karol S. Bruzik, and Ming-Daw Tsai, Biochemistry 36, 6633-6642 (1997).
117. "Natural Product Chemistry: From Plants to Human." Ming-Daw Tsai, J. Chin. Chem. Soc. 44, 183-186 (1997).
118. "Use of Unnatural Amino Acids to Probe the Importance of the Aromaticity in Tyrosine-95 and the Ring Size in Proline-17 in Adenylate Kinase." Z. Zhao, X. Liu, Z. Shi, B. Huang, R.-T. Jiang, and M.-D. Tsai, Youji Huaxue 17, 20-23 (1997).
119. "Mechanism of PI-Specific Phospholipase C. 2. Reversal of a Thio Effect by Site-Directed Mutagenesis." Robert J. Hondal, Zhong Zhao, Karol S. Bruzik, and Ming-Daw Tsai, J. Am. Chem. Soc. 119, 5477-8 (1997).
120. "DNA Polymerase b: 4. Multiple Conformational Changes in the Mechanism of Catalysis". Xuejun Zhong, Smita S. Patel, Brian G. Werneburg, and Ming-Daw Tsai, Biochemistry 36, 11891-11900 (1997).
121. "Mechanism of PI-Specific Phospholipase C. 3. Elucidation of the Catalytic Mechanism and Comparison with Ribonuclease A." Robert J. Hondal, Zhong Zhao, Suzette R. Riddle, Alexander V. Kravchuk, Hua Liao, Karol S. Bruzik, and Ming-Daw Tsai, J. Am. Chem. Soc. 119, 9933-9934 (1997).
122. "Crystal Structure of the Complex of Bovine Pancreatic Phospholipase A2 with a Transition State Analogue." K. Sekar, A. Kumar, X. Liu, M.-D. Tsai, M. Gelb, and M. Sundaralingam, Acta Crystallogr. D. Biol. Crystallogr. 54, 334-341 (1998).
123. "1.72 A Resolution Refinement of the Trigonal Form of Bovine Pancreatic PhospholipaseA2." K. Sekar, A. Kumar, X. Liu, M.-D. Tsai, M. Gelb, and M. Sundaralingam, Acta Crystallogr. D. Biol. Crystallogr. 54, 342-346 (1998).
124. "DNA Polymerase b: 5. Effects of Gapped DNA Substrates on dNTP Specificity, Fidelity, Processivity, and Conformational Changes." Jinwoo Ahn, Vadim Kraynov, Xuejun Zhong, Brian G. Werneburg, and Ming-Daw Tsai, Biochem. J. 331, 79-87 (1998).
125. "DNA Polymerase b. 6. Dissecting the Functional Roles of the Two Metal Ions with Cr(III)dTTP" by Xuejun Zhong, Smita S. Patel, and Ming-Daw Tsai, J. Am. Chem. Soc. 120, 235-236 (1998).
126. "Tumor Suppressor p16INK4A: Determination of Solution Structure and Analyses of Its Interaction with Cyclin-Dependent Kinase 4". In-Ja L. Byeon, Junan Li, Karen Ericson, Thomas L. Selby, Anton Tevelev, Hee-Jung Kim, Paul O'Maille, and Ming-Daw Tsai, Molecular Cell 1, 421-431 (1998).
127. "Mechanism of PI-Specific Phospholipase C. 4. A Unified View of the Catalytic Mechanism." Robert J. Hondal, Zhong Zhao, Alexander V. Kravchuk, Hua Liao, Suzette R. Riddle, Xiangjun Yue, Karol S. Bruzik, and Ming-Daw Tsai, Biochemistry 37, 4568-4580 (1998).
128. "Mechanism of PI-Specific Phospholipase C. 5. The Mechanism of PI-PLC Revealed by Protein Engineering and Thio-PI Analogs." Robert J. Hondal, Zhong Zhao, Alexander V. Kravchuk, Hua Liao, Suzette R. Riddle, Karol S. Bruzik, and Ming-Daw Tsai, in Phosphoinositides: Chemistry, Biochemistry and Biomedical Applications, K. S. Bruzik, Ed. ACS Symp. Ser. vol. 718, pp. 109-120 (1998).
129. "Lysines 53 and 56 Control the Anion-Induced Interfacial k*cat-Activation of Pancreatic Phospholipase A2." Joseph Rogers, Bao-Zhu Yu, Ming-Daw Tsai, Otto Berg, and Mahendra K. Jain, Biochemistry 37, 9549-9556 (1998).
130. “Identification of a Novel Catalytic Triad with Dual Functions in Enzymatic Cleavage of the P-O Bond”. Robert J. Kubiak, Robert J. Hondal, Xiangjun Yue, Ming-Daw Tsai, and Karol S. Bruzik, J. Am. Chem. Soc. 121, 488-489 (1999).
131. “Crystal Structures of the Catalytic Site Mutants D99A and H48Q and the Calcium Loop Mutant D49E of Phospholipase A2”. K. Sekar, R. Biswas, Y. Li, M.-D. Tsai, and M. Sundaralingam, Acta Crystallogr. D55, 443-447 (1999).
132. “Structural Analysis of Phospholipase A2 from Functional Perspective. 1. Functionally Relevant Solution Structure and Roles of the Hydrogen Bonding Network”. Chunhua Yuan, In-Ja L. Byeon, Yishan Li, and Ming-Daw Tsai, Biochemistry 38, 2909-2918 (1999).
133. “Structural Analysis of Phospholipase A2 from Functional Perspective. 2. Characterization of a Molten Globule-like State Induced by Site-Specific Mutagenesis”. Chunhua Yuan, In-Ja L. Byeon, Ming Jye Poi, and Ming-Daw Tsai, Biochemistry 38, 2919-2929 (1999).
134. “Tumor Suppressor INK4: 3. Determination of the Solution Structure of p18INK4C and Demonstration of the Functional Significance of Loops in p18INK4C and p16INK4A.” Junan Li, In-Ja L. Byeon, Karen Ericson, Ming Jye Poi, Paul O’Maille, Thomas Selby, and Ming-Daw Tsai, Biochemistry 38, 2930-2940 (1999).
135. “Contributions of Residues of Pancreatic Phospholipase A2 to Interfacial Binding, Catalysis and Activation”. Bao-Zhu Yu, Joseph Rogers, Ming-Daw Tsai, Charles Pidgeon, and Mahendra K. Jain, Biochemistry 38, 4875-4884 (1999).
136. “Nucleoside Monophosphate Kinases: Structure, Mechanism, and Substrate Specificity.” Honggao Yan and Ming-Daw Tsai, Adv. Enzymol. And Related Area of Mol. Biol. 73: Mechanism of Enzyme Action, D. L. Purich, Ed., pp. 103-134 (1999).*
137. “Pancreatic Phospholipase A2: New Views on Old Issues”. Chunhua Yuan and Ming-Daw Tsai, BBALIP – Special Thematic Issue on “Lipids in the Center”, BBA-Mol. Cell. Biol. L 1441, 215-222 (1999).
138. “Tumor Suppressor INK4: Comparisons of Conformational Properties between p15INK4B, p16INK4A, and p18INK4C.” Chunhua Yuan, Junan Li, Thomas L. Selby, In-Ja L. Byeon, and Ming-Daw Tsai, J. Mol. Biol. 294, 201-211 (1999).
139. “Structure and Function of A New Phosphopeptide Binding Domain Containing the FHA2 of Rad53” by Hua Liao, In-Ja L. Byeon, and Ming-Daw Tsai, J. Mol. Biol. 294, 1041-1049 (1999).
140. “Tumor Suppressor INK4: Quantitative Structure-Function Analyses of p18INK4C as an Inhibitor of Cyclin-Dependent Kinase 4.” Junan Li, Ming Jye Poi, Dongyan Qin, Thomas L. Selby, In-Ja Byeon, and Ming-Daw Tsai, Biochemistry 39, 649-657 (2000).
141. “Structure-Function Relationship of the INK4 Family of Tumor Suppressors”. Junan Li, In-Jia L. Byeon, Ming Jye Poi, Karen Ericson, Thomas Selby, Paul O’Maille, Dongyan Qin, and Ming-Daw Tsai, in DNA Alterations in Cancer: Genetic and Epigenetic Changes, Melanie Ehrlich, Ed., BioTechniques Books, Eaton Publishing, pp. 71-84 (2000).
142. “Tumor Suppressor INK4: Refinement of p16INK4A Structure and Determination of p15INK4B Structure by Comparative Modeling and NMR Data”. Chunhua Yuan, Thomas L. Selby, Junan Li, In-Ja Byeon, and Ming-Daw Tsai, Protein Science 9, 1120-1128 (2000).
143. “Kinetic Isotope Effects and Stereochemical Studies on a Ribonuclease Model: Hydrolysis Reactions of Uridine-3’-Nitrophenyl Phosphate”. Alvan C. Hengge, Karol S. Bruzik, Aleksandra E. Tobin, W. W. Cleland, and Ming-Daw Tsai, Bioorg. Chem. 28, 119-133 (2000).
144. “Anionic Interface Preference of Secreted Phospholipase A2: The Kinetic and Structural Basis”. Bao-Zhu Yu, Ming Jye Poi, U.A. Ramagopal, Rinku Jain, S. Ramakumar, Otto Berg, Ming-Daw Tsai, K. Sekar, and Mahendra Kumar Jain, Biochemistry 39, 12312-12323 (2000).
145. “Structure and Specificity of the Interaction between the FHA2 Domain of Rad53 and Phosphotyrosyl Peptides”. Peng Wang, In-Ja L. Byeon, Hua Liao, Kirk Beebe, Suganya Yongkiettrakul, Dehua Pei, and Ming-Daw Tsai, J. Mol. Biol. 302, 927-940 (2000).
146. “Structure of the FHA1 Domain of Yeast Rad53 and Identification of Binding Sites for both FHA1 and Its Target Protein Rad9”. Hua Liao, Chunhua Yuan, Mei-I Su, Suganya Yongkiettrakul, Dongyan Qin, Hongyuan Li, In-Ja L. Byeon, Dehua Pei, and Ming-Daw Tsai, J. Mol. Biol. 304, 941-951 (2000).
147. “DNA Polymerase b: Contributions of Template-Positioning and dNTP Triphosphate-Binding Residues to Catalysis and Fidelity.” Vadim S. Kraynov, Alexander K. Showalter, Jia Liu, Xuejun Zhong and Ming-Daw Tsai, Biochemistry 39, 16008-16015 (2000).
148. “Somatic INK4a-ARF Locus Mutations: A Significant Mechanism of Gene Inactivation in Squamous Cell Carcinomas of the Head and Neck.” Ming J. Poi, Thomas Yen, Junan Li, Huijuan Song, Jas C. Lang, Dave E. Schuller, Dennis K. Pearl, Bruce C. Casto, Ming-Daw Tsai, and Christopher M. Weghorst, Molecular Carcinogenesis 30, 26-36 (2001). [pdf]
149. “A DNA Polymerase with Specificity for Five Base Pairs”. Alexander K. Showalter and Ming-Daw Tsai, J. Am. Chem. Soc. 123, 1776-1777 (2001). [pdf]
150. “Insight into the Catalytic Mechanism of DNA Polymerase b: Structures of Intermediate Complexes”. Joseph W. Arndt, Weimin Gong, Xuejun Zhong, Alexander K. Showalter, Jia Liu, Christopher A. Dunlap, Zheng Lin, Chad Paxson, Ming-Daw Tsai, and Michael K. Chan, Biochemistry 40, 5368 -5375 (2001). [pdf]
151. “Involvement of Arg…Asp…His Catalytic Triad in Enzymatic Cleavage of Phosphodiester Bond”. Robert J. Kubiak, Xiangjun Yue, Robert J. Hondal, Cornelia Mihai, Ming-Daw Tsai, and Karol S. Bruzik, Biochemistry 40, 5422-5432 (2001).
152. “Mechanism of PI-PLC: Origin of Unusually High Non-bridging Thio Effects”. Alexander V. Kravchuk, Li Zhao, Robert J. Kubiak, Karol S. Bruzik, and Ming-Daw Tsai, Biochemistry 40, 5433-5439 (2001).
153. “DNA Polymerase b: Pre-steady-State Kinetic Analyses of dATPaS Stereoselectivity and Alteration of the Stereoselectivity by Varying Metal Ions and by Site-Directed Mutagenesis.” Jia Liu and Ming-Daw Tsai, Biochemistry 40, 9014-9022 (2001).
154. “Interfacial Enzymology: The Phospholipase A2 Paradigm”. Otto G. Berg, Michael Gelb, Ming-Daw Tsai, and Mahendra K. Jain, Chemical Reviews 101, 2613-2653 (2001).
155. “Structure and Function of the Mutagenic African Swine Fever Virus DNA Polymerase X” by Alexander K. Showalter, In-Ja L. Byeon, Mei-I Su, and Ming-Daw Tsai, Nature Structural Biology 8, 942-946 (2001).
156. “Solution Structures of Two FHA1-Phosphothreonine Peptide Complexes Provide Insight into the Structural Basis of the Ligand Specificity of FHA1 from Yeast Rad53.” Yuan, C., Yongkiettrakul, S., Byeon, I.-J. L., Zhou, S., & Tsai, M.-D., J. Mol. Biol. 314, 563-575 (2001).
157. “Solution Structure of the Yeast Rad53 FHA2 Complexed with a Phosphothreonine Peptide pTXXL: Comparison with the Structures of FHA2-pYXL and FHA1-pTXXD Complexes.” Byeon, I. -J. L., Yongkiettrakul, S., & Tsai, M.-D. J. Mol. Biol. 314, 577-588 (2001).
158. “Novel Insights into the INK4-CDK4/6-Rb Pathway: Counteraction of Gankyrin Against INK4 Proteins Regulates the CDK4-Mediated Phosphorylation of Rb”. Junan Li and Ming-Daw Tsai, Biochemistry 41, 3977-3983 (2002).
159. “FHA: A Signal Transduction Domain with Diverse Specificity and Function”. Ming-Daw Tsai, Structure 10, 887-888 (2002).
160. “Structure-based Combinatorial Protein Engineering (Scope)” by Paul E. O’Maille, Marina Bakhtina, and Ming-Daw Tsai, J. Mol. Biol. 321, 677-691 (2002).
161. “A Reexamination of the Nucleotide Incorporation Fidelity of DNA Polymerases”. Alexander K. Showalter and Ming-Daw Tsai, Biochemistry 41, 10571-10576 (2002). [New Concepts in Biochemistry]
162. “Use of 2-Aminopurine Fluorescence as a Probe in Kinetic Analyses of DNA Polymerase b”. Christopher A. Dunlap and Ming-Daw Tsai, Biochemistry 41, 11226-11235 (2002).
163. “Observation of Additional Calcium Ion in the Crystal Structure of the Triple Mutant K56,120,121M of Bovine Pancreatic Phospholipase A2”. V. Rajakannan, M. Yogavel, Ming-Jye Poi, A. Jeya Prakash, J. Jeyakanthan, D. Velmurugan, Ming-Daw Tsai and K. Sekar, J. Mol. Biol. 324, 755-762 (2002).
164. “A Novel Calcium-Dependent Bacterial Phosphatidylinositol-Specific Phospholipase C Displaying Unprecedented Magnitudes of Thio Effect, Inverse Thio Effect, and Stereoselectivity”. Li Zhao, Yinghui Liu, Karol S. Bruzik, and Ming-Daw Tsai, J. Am. Chem. Soc. 125, 22-23 (2003).
165. “Engineering a Catalytic Metal Binding Site into a Calcium-independent Phosphatidylinositol-Specific Phospholipase C Leads to Enhanced Stereoselectivity”. Alexander V. Kravchuk, Li Zhao, Karol S. Bruzik, and Ming-Daw Tsai, Biochemistry 42, 2422-2430 (2003).
166. “Application of BrØnsted-type LFER in the Study of the Phospholipase C Mechanism”. Cornelia Mihai, Alexander V. Kravchuk, Ming-Daw Tsai and Karol S. Bruzik, J. Am. Chem. Soc. 115, 3236-3243 (2003).
167. “Expression and Characterization of Syrian Golden Hamster p16, a Homologue of Human Tumor Suppressor p16INK4A.” Junan Li, Dongyan Qin, Thomas J. Knobloch, Ming-Daw Tsai, Christopher M. Weghorst, W. Scott Melvin, and Peter Muscarella, Biochem. Biophys. Res. Commun. 304, 241-247 (2003).
168. “Interaction of Monodisperse Amphiphiles at the i-Face of Secreted Phospholipase A2”. Bao-Zhu Yu, Rafael Apitz-Castro, Ming-Daw Tsai, and Mahendra K. Jain, Biochemistry 42, 6293-6301 (2003).
169. “A Low Barrier Hydrogen Bond Between Histidine of Secreted Phospholipase A2 and a Transition State Analog Inhibitor”. Ming Jye Poi, John W. Tomaszewski, Chunhua Yuan, Christopher A. Dunlap, Niels H. Andersen, Michael H. Gelb, and Ming-Daw Tsai, J. Mol. Biol. 329, 997-1009 (2003).[pdf]
170. “Direct Binding of the N-terminus of HTLV-1 Tax Oncoprotein to Cyclin-dependent Kinase 4 Is a Dominant Path to Stimulate the Kinase Activity”. Junan Li, Hongyuan Li, and Ming-Daw Tsai, Biochemistry 42, 6921-6928 (2003). [pdf]
171. “Biocatalysis and Biotransformation Enzymology in the Genomic Era – Editorial Overview.” Tadhg P. Begley and Ming-Daw Tsai, Curr. Opin. Chem. Biol. 7, 228-229 (2003).
172. “Diverse but Overlapping Functions of the Two Forkhead-associated (FHA) Domains in Rad53 Checkpoint Kinase Activation.” Brietta L. Pike, Suganya Yongkiettrakul, Ming-Daw Tsai, and Jorg Heierhorst, J. Biol. Chem. 278, 30421-30424 (2003). [pdf]
173. “Frequent p16INK4A/CDKN2A Alterations in Chemically Induced Syrian Golden Hamster Pancreatic Tumors”. Junan Li, Christopher M. Weghorst, Masahiro Tsutsumi, Ming J. Poi, Thomas J. Knobloch, Bruce C. Casto, W. Scott Melvin, Ming-Daw Tsai, and Peter Muscarella, Carcinogenesis, 2004 Feb;25(2):263-8. [pdf]
174. “Crystal Structures of the Free and Anisic Acid Bound Triple Mutant of Phospholipase A2”. K. Sekar, S. Vaijayanthi Mala, M. Yogavel, D. Velmurugan, Ming-Jye Poi, B. S. Vishwanath, T. V. Gowda, A. Arokia Jeyaprakash and M.-D. Tsai, J. Mol. Biol. 333, 367-376 (2003). [pdf]
175. “Identification of Potential Binding Sites for the FHA Domain of Human Chk2 by in vitro Binding Studies.” Dongyan Qin, Hyun Lee, Chunhua Yuan, Yong Ju, and Ming-Daw Tsai, Biochem. Biophys. Res. Commun.311(4):803-8. (2003). [pdf]
176. “An NF-kB-Specific Inhibitor, IkBa, Binds to and Inhibits Cyclin-Dependent Kinase 4”. Junan Li, Sang Hoon Joo, and Ming-Daw Tsai, Biochemistry, 2003 Nov 25;42(46):13476-83. [pdf]
177. “Structure of human Ki67 FHA domain and its binding to a phosphoprotein fragment from hNIFK reveal unique recognition sites and new views to the structural basis of FHA domain functions.” Hongyuan Li, In-Ja L. Byeon, Yong Ju, and Ming-Daw Tsai, J. Mol. Biol., 335(1):371-81 (2003). [pdf]
178. The Ligand Specificity of Yeast Rad53 FHA Domains at the +3 Position Is Determined by Non Conserved Residues” by Suganya Yongkiettrakul, In-Ja L. Byeon, and Ming-Daw Tsai, Biochemistry 43, 3862-3869 (2004). [pdf]
179. “Mdt1, a Novel Rad53 FHA1 Domain-Interacting Protein, Modulates DNA Damage Tolerance and G2/M Cell Cycle Progression in Saccharomyces cerevisiae”. Brietta L. Pike, Suganya Yongkiettrakul, Ming-Daw Tsai, and Jorg Heierhorst. Mol. Cell. Biol. 24, 2779-2788 (2004).
180. “The Nuclear Protein p34SEI-1 Regulates the Kinase Activity of Cyclin-dependent Kinase 4 in a Concentration-dependent Manner.” Junan Li, W. Scott Melvin, Ming-Daw Tsai, and Peter Muscarella, Biochemistry. 2004 Apr 13;43(14):4394-9. [pdf]
181. “Gene Library Synthesis by Structure-based Combinatorial Protein Engineering (SCOPE).” Paul E. O’Maille, Ming-Daw Tsai, and Joseph P. Noel, Methods in Enzymology 388, 75-91 (2004).
182. “The Catalytic Role of the Aspartate in a Short Strong Hydrogen Bond of Asp274×××His32 Catalytic Dyad in Phosphatidylinositol-specific Phospholipase C Can Be Substituted by a Chloride Ion.” Li Zhao, Hua Liao, and Ming-Daw Tsai, J. Biol. Chem. 279, 31995-32000 (2004).
183. “Solution Structure of Human Oncogenic Protein Gankyrin Containing Seven Ankyrin Repeats and Analysis of Its Structure-function Relationship”. Chunhua Yuan, Junan Li, Anjali Mahajan, Ming Jye Poi, In-Ja L. Byeon, and Ming-Daw Tsai, Biochemistry 43, 12152-12161 (2004).
184. “Stereochemistry in Understanding Enzyme Kinetics and Mechanism.” Ming-Daw Tsai, Li Zhao, and Brandon Lamarche, Encyclopedia in Biological Chemistry 2, 45-50 (2004).
185. “Atomic resolution (0.97Å) structure of the triple mutant (K53,56,121M) of bovine pancreatic phospholipase A2”. K. Sekar, V. Rajakannan, D. Gayathri, D. Velmurugan, M.-J. Poi, M. Dauter, Z. Dauter and M.-D. Tsai, Acta Cryst. F61, 3-7 (2005).
186. “Unusual Four-bond Secondary H/D Isotope Effect Supports a Short-Strong Hydrogen Bond between Phospholipase A2 and a Transition State Analog Inhibitor.” Chunhua Yuan, Shengjiang Tu, Michael H. Gelb, and Ming-Daw Tsai, Biochemistry, in press (2005).
187. “Use of Viscogens, dNTPaS and Rhodium(III) as Probes in Stopped Flow Experiments to Obtain New Evidence for the Mechanism of Catalysis by DNA Polymerase b”. Marina Bakhtina, Soojin Lee, Yu Wang, Chris Dunlap, Brandon Lamarche, and Ming-Daw Tsai, Biochemistry, in press (2005).
188. “An Error-Prone Viral DNA Ligase.” Brandon Lamarche, Alex Showalter, and Ming-Daw Tsai, Biochemistry, in press (2005).
189. “Dissection of CDK4-binding and Transactivation Activities of p34SEI-1 and Comparison between Functions of p34SEI-1 and p16INK4”. Junan Li, Peter Muscarella, Sang Hoon Joo, Thomas, J. Knobloch, W. Scott Melvin, Christopher, M. Weghorst, and Ming-Daw Tsai, Biochemistry, in press (2005).
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