1.      Dalbey, R. E., Wells, J. A. and Yount, R. G. (1983), "Trapping of Transition Metal Nucleotide Complexes in Myosin Subfragment One Following Thiol Cross-Linking", Biochemistry, 22, 490-496.

  1. Dalbey, R. E., Weiel, J. and Yount, R. G. (1983), "Fluorescence Energy Transfer Measurements of SH-1 and SH-2 Distances in Myosin Subfragment One (SF1)", Biochemistry, 22, 4696-4706.
  2. Dalbey, R. E., Weiel, J., Perkins, J. W. and Yount, R. G. (1984), "Resolution of Multiple Lifetimes in Heterogeneous Systems by Phase-Modulation Fluorometry", J. Biochem. Biophys. Methods, 9, 251-266.
  3. Dalbey, R. E. and Wickner, W. (1985), "Leader Peptidase Catalyzes Release of Exported Proteins from the Outer Surface of the Escherichia coli Plasma Membrane", J. Biol. Chem., 260, 15925-15931.
  4. Dalbey, R. E. and Wickner, W. (1986), "The Role of the Polar, Carboxy-terminal Domain of Escherichia coli Leader Peptidase in Its Translocation Across the Plasma Membrane", J. Biol. Chem., 261, 13844-13849.
  5. Dalbey, R.E., Kuhn, A. and Wickner, W. (1986), "Leader Peptidase from E. coli", Microbiology-1986, 234-237; ASM-Washington, D.C.
  6. Dalbey, R.E., and Wickner, W. (1987), "A Small Domain of Escherichia coli Leader Peptidase has a Critical Role in its Membrane Assembly", Science, 235, 783-787.
  7. Dalbey, R. E., Kuhn A., Kreil, G., Rice, M.C. and Wickner, W. T. (1987), "Mechanisms of Membrane Assembly and Protein Secretion", Chemical Scripta, 27B, 245-248.
  8. Dalbey, R. E., Kuhn A. and Wickner, W. (1987), "The Internal Signal Sequence of Escherichia coli Leader Peptidase is Necessary, but Not Sufficient, For Its Rapid Membrane Assembly", J. Biol. Chem., 262, 13241-13245.
  9. Von Heijne,G., Wickner, W. and Dalbey, R.E. (1988), "The Cytoplasmic Domain of Escherichia coli Leader Peptidase is a Translocation Poison Sequence", Proc. Natl. Acad. Sci. U.S.A., 85, 3363-3366.
  10. Dalbey, R. E., Wickner, W. (1988), "Characterization of the Internal Signal-Anchor Domain of Escherichia coli Leader Peptidase", J. Biol. Chem., 263, 404-408.
  11. Moore, K.E., Dalbey, R. E. and Wickner, W. (1988), "In Vitro Membrane Assembly of Escherichia coli Leader Peptidase: Integration of an Integral Membrane Protein with Known Topology", J. Bacteriol., 170, 4395-4398.
  12. Laws, J.K. and Dalbey, R.E. (1989), "Positive Charges in the Cytoplasmic Domain of Escherichia coli Leader Peptidase Prevent an Apolar Domain from Functioning as a Signal", EMBO J., 8, 2095-2099.
  13. Zhu, H.Y. and Dalbey, R.E. (1989), "Both a Short Hydrophobic Domain and a Carboxyl-terminal Hydrophilic Region Are Important for Signal Function in the Escherichia coli Leader Peptidase", J. Biol Chem., 264, 11833-11838.
  14. San Millan, J.L., Boyd, D., Dalbey, R. E., Wickner, W. and Beckwith, J. (1989), "The Use of phoA Fusions to Study the Topology of the E. coli Inner Membrane Protein Leader Peptidase", J. Bacteriol., 171, 5536-5541.
  15. Dalbey, R. E. (1990), "Positively Charged Residues are Determinants of the Membrane Orientation of Proteins", Trends in Biochemical Sciences, 15, 253- 257.
  16. Kuhn, A., Zhu, H.Y., and Dalbey, R. E. (1990), "Efficient Translocation of Positively Charged Residues of M13 Procoat Protein Across the Membrane Excludes Electrophoresis as the Primary Force for Membrane Insertion", EMBO J., 9, 2385-2389.
  17. Bilgin, N., Lee, J.I., Zhu, H.Y., Dalbey, R.E., and von Heijne, G. (1990), "Mapping of Catalytically Important Domains in Escherichia coli Leader Peptidase", EMBO J., 9, 2717-2722.
  18. Dalbey, R.E. (1991), "In Vivo Protein Translocation Into or Across the Bacterial Plasma Membrane", Methods in Cell Biology, 34, 39-60.
  19. Shen, L. M., Lee, J.I., Cheng, S., Jütte, H., Kuhn, A., and Dalbey, R.E. (1991), "Use of Site-Directed Mutagenesis to Define the Limits of Sequence Variation Tolerated for Processing of the M13 Procoat Protein By the Escherichia coli Leader Peptidase", Biochemistry, 30, 11775-11781.
  20. Dalbey, R.E. (1991), "Leader Peptidase--A Membrane-Bound Protease Required for Protein Export", Molecular Microbiology, 5, 2855-2860.
  21. Lee, J. I., Kuhn A. and Dalbey, R. E., (1991), "Distinct Domains of an Oligotopic Membrane Protein Are Sec-Dependent and Sec-Independent for Membrane Insertion", J. Biol. Chem., 267, 938-943.
  22. Sung, M. and Dalbey, R.E. (1992), "Identification of Potential Active-Site Residues in the Escherichia coli Leader Peptidase", J. Biol. Chem., 267, 13154-13159.
  23. Dalbey, R.E. and von Heijne, G. (1992), "Signal Peptidase in Prokaryotes and Eukaryotes - A New Protease Family", Trends in Biochemical Sciences, 17, 474-478.
  24. Cheng, S., Tschantz, W., Sung, M. and Dalbey, R.E. (1992), "Sec-Dependent and Sec-Independent Mechanisms of Protein Insertion into Bacterial Membranes", Proceedings of the 25th Jerusalem Symposium on Quantum Chemistry and Biochemistry, Membrane Proteins: Structure, Interactions, and Models, pages 383-392, Kluwer Academic Publishers, Dordech, England.
  25. Geller, B.L., Zhu, H-Y., Cheng, S., Kuhn, A., and Dalbey, R.E. (1993), "Charged Residues Render Pro-OmpA Potential-Dependent for Initiation of Membrane Translocation", J. Biol. Chem., 268, 9442-9447.
  26. Tschantz, W. R., Sung, M., Delgado-Partin, V. M., and Dalbey, R. E. (1993), "A Serine and Lysine Residue Implicated in the Catalytic Mechanism of the E. coli Leader Peptidase", J. Biol. Chem., 268, 27349-27354.
  27. Dalbey, R. E. (1994), "Leader Peptidase" in: "Guide to the Secretory Pathway"(J. Rothbatt, T. Stevens, P. Novick, Eds.) Sambrook and Tooze Scientific Publisher (Oxford University Press).
  28. Tschantz, W. R. and Dalbey, R. E. (1994), "Bacterial Leader Peptidase 1", Methods Enzymol., 244, 285-301.
  29. Dalbey, R. E. (1994), "Bacterial Signal Peptidase 1", in: "Signal Peptidases"(G. von Heijne, Editor) R.G. Landes Publishing Co.
  30. Cao, G. and Dalbey, R. E. (1994), "Translocation of Amino-terminal Tails across the Plasma Membrane", EMBO J., 13, 4662-4669.
  31. Cao, G., Cheng, S., Whitley, P., von Heijne, G., Kuhn, A., and Dalbey, R. E. (1994), "Synergistic Insertion of Two Hydrophobic Regions Drives Sec-Independent Membrane Protein Assembly", J. Biol. Chem., 269, 26898-26903.
  32. Kuhn, A., Kiefer, D., Kohne, C., Zhu, H-Y., Tschantz, W.R., and Dalbey, R.E. (1994), "Evidence for a Loop-Like Insertion Mechanism of Pro-OmpA Into the Inner Membrane of Escherichia coli", Eur. J. Biochem., 226, 891-897.
  33. Chatterjee, S., Suciu, D., Dalbey, R. E., Kahn, P. C., and Inouye, M. (1995), "Determination of Km and kcat for Signal Peptidase 1 Using a Full Length Secretory Precursor, pro-0mpA-nuclease," A, J. Mol. Biol., 245, 311-314.
  34. Cao, G., Kuhn, A. and Dalbey, R.E. (1995), "The Translocation of Negatively Charged Residues Across the Membrane is Driven by the Electrochemical Potential - - Evidence For an Electrophoresis-like Membrane Transfer Mechanism", EMBO J., 14, 866-875.
  35. Tschantz, W., Paetzel, M., Cao, G., Suciu, D., Inouye, M., and Dalbey, R.E. (1995), "The Characterization of a Soluble, Catalytically Active Form of E. coli Leader Peptidase: Requirement of Detergent or Phospholipid for Optimal Activity", Biochemistry, 34, 3935-3941.
  36. Paetzel, M., Tschernaia, M., Strynadka, N., Tschantz, W., Cao, G., Dalbey, R.E., and James, M.N.G. (1995), "Crystallization of the Soluble, Catalytically Active Form of the E. coli Leader Peptidase," Proteins: Structure, Function and Genetics, 23, 122-125.
  37. Dalbey, R.E. (1995), "Signal Peptidases: An Overview", ASM News, 61, 586-590.
  38. Dalbey, R.E., Kuhn, A. and von Heijne, G. (1995). "Directionality in Protein Translocation Across Membranes: The N-tail Phenomenon", Trends in Cell Biology, 5, 380-383.
  39. Dalbey, R.E., (1997). "Signal Peptidase 1 (Prokaryote)", Handbook of Proteolytic Enzymes, in press.
  40. Paetzel, M. and Dalbey, R.E. (1997). "Catalytic Hydroxyl/Amine Dyads within Serine Proteases ", Trends in Biochemical Sciences, 22, 28-31.
  41. Kiefer, D., Hu, X., Dalbey, R.E. and Kuhn, A. (1997). "Acidic Residues Determine the Membrane Topology of the Pf3 Coat Protein ", EMBO. J., 16, 2197-2204.
  42. Dalbey, R.E., Lively, M. O., Bron, S. and van Dijl, J. M. (1997). "The Enzymology of the Type I Signal Peptidase ", Protein Science, 6, 1-10.
  43. Paetzel, M., Strynadka, N.C.J., Tschantz, W.R., Casareno, R., Bullinger, P.R. and Dalbey, R.E. (1997). "Use of Site-Directed Chemical Modification to Study an Essential Lysine in Escherichia coli Leader Peptidase ", J. Biol. Chem., 272, 9994-10003.
  44. Paetzel, M., Strynadka, N.C.J., James, M.N.G. and Dalbey, R.E. (1997). "Crystallization and Preliminary X-Ray Analysis of a Soluble, Catalytically Active Form of Escherichia coli Type 1 Signal Peptidases", Proteolysis in Cell Function, 256-261.
  45. Paetzel, M. and Dalbey, R.E. (1997). "Investigating the Structural and Chemical Flexibility of the Essential Lysine in Escherichia coli Type 1 Signal Peptidase by the Use of Site-Directed Chemical Modification", Proteolysis in Cell Function, 262-267.
  46. Delgado-Partin, V. M. and Dalbey, R. E. (1998). "The Proton Motive Force, Acting on Acidic Residues, Promotes Translocation of Amino-terminal Domains of Membrane Proteins When the Hydrophobicity of the Translocation Signal is Low". J. Biol. Chem., 273, 9927-9934.
  47. van Klompenburg, W., Paetzel, M., de Jong, J. M., Dalbey, R. E., Demel, R. A., von Heijne, G. and de Kruijff, B. (1998). The Catalytic Domain of Signal Peptidase Inserts in a Phosphatidyl Ethanolamine Dependent Way in the Outer Leaflet of the E. coli Inner Membrane", FEBS Lett., 431, 75-79.
  48. Dalbey, R.E., (1998). "Signal Peptidase 1", Handbook of Proteolytic Enzymes (Barrett, A., Woessner, F. Jr., and Rawling, N., Eds.) Academic Press, 447-450.
  49. Paetzel, M., Dalbey, R. E., and Strynadka, N. C. J. (1998),"Crystal Structure of a Bacterial Signal Peptidase in Complex with a ß-lactam Inhibitor", Nature 396, 186-190.
  50. Dalbey, R. E. and Robinson, C. (1999),"Protein Translocation into and across the E. coli Plasma and Plant Thylakoid Membranes", Trends Biochem. Sci. 24, 17-22.
  51. Schuenemann, T. A., Delgado-Nixon, V. M., and Dalbey, R. E. (1999)."Direct Evidence that the Proton Motive Force Inhibits Membrane Translocation of Positively Charged Residues Within Membrane Proteins", J. Biol. Chem., 274, 274, 6855-6864.
  52. Klenotic, P. A., Carlos, J. L., Samuelson, J. C., Schuenemann, T. A., Tschantz, W. R., Paetzel, M., Strynadka, N. C. J. and Dalbey, R. E. (2000). "The Role of the Conserved Box III residues in the Active Site of the E. coli type I Signal Peptidase", J. Biol. Chem., 275 6490-6498.
  53. Paetzel, M., Dalbey, R. E., and Strynadka, N. C. J. (2000). "The Structure and Mechanism of Bacterial Type I Signal Peptidase: a Potential Antibiotic Target", Pharmacology and Therapeutics, 87, 27-47.
  54. Dalbey, R. E. and Kuhn, A. (2000). "Evolutionarily Related Insertion Pathways of Bacterial, Mitochondrial and Thylakoid Membrane Proteins", Ann. Rev Cell Develop. Biol. 16, 51-87.
  55. Carlos, J. L., Klenotic, P. A., Paetzel, M., Strynadka, N. C. J. and Dalbey, R. E. (2000). "Transition State Stabilization by Ser88 in the Oxyanion Hole of E. coli Type 1 Signal Peptidase", Biochemistry, 39, 7276-7283.
  56. Samuelson, J., Chen, M., Jiang, F., Wiedmann, M., Brunner, J., Phillips, G. and Dalbey, R. (2000). "YidC is Required for Membrane Protein Insertion in E. coli", Nature, 406, 636-641.
  57. Dalbey, R. E., Jiang, F., Chen, M. and Samuelson, J. (2000). "In vivo Assembly of Transporters and other Membrane Proteins". Current Opinions in Cell Biol., 12, 435-442.

59.  Carlos, J., Paetzel, M., Brubaker, G., Karla, A., Ashwell, C., Lively, M. O., Cao,G. and Dalbey,R. E. (2000).”The Role of the Membrane-Spanning Domain of Type I Signal Peptidases in Substrate Cleavage Site Selection”, J. Biol. Chem. 275, 38813-38822.

  1. Urbanus, M. L., Scotti, P. A., Froderberg, L., Saaf, A., de Gier, J. W., Brunner, J., Samuelson, J. C., Dalbey, R. E., Oudega, B. and Luirink, J. (2001). “Sec-dependent Membrane Protein Insertion: Sequential Interaction of Nascent FtsQ with SecY and YidC”, EMBO Rep 2, 524-5
  2. Beck, K., Eisner, G., Trescher, D., Dalbey, R. E., Brunner, J. and Muller, M. (2001). “YidC, an Assembly Site for Polytopic Escherichia coli Membrane Proteins Located in Immediate Proximity to the SecYE Translocon and Lipids”, EMBO Rep 2, 709-714.
  3. Samuelson, J. C., Jiang, F., Yi Liang, Chen M., de Gier, J-W., Kuhn, A. and Dalbey, R. E. (2001). “Function of YidC for the Insertion of M13 Procoat Protein in E. coli: J. Biol. Chem., 276, 34847-34852.
  4. Carlos, J., Klenotic, P., Paetzel, M., and Strynadke, N. C. J. and Dalbey, R. E. (2001). “Bacterial Type 1 Signal Peptidases“, The Enzymes, Third Edition Vol. 22, 27-55, Academic Press.
  5. van den Brink-van der Laan, E., Dalbey, R. E., Demel, R. A., Killian, J. A., and de Kruijff, B. (2001). “Effect of Nonbilayer Lipids on Membrane Binding and Insertion of the Catalytic Domain of Leader Peptidase”, Biochemistry 40, 9677-9684.
  6. Chen, M., Samuelson, J. C., Jiang, F., Muller, M., Kuhn, A. and Dalbey, R. E. (2002).  “Direct Interaction of YidC with the Sec-independent Pf3 Coat Protein During its Membrane Protein Insertion“, J. Biol. Chem., 277, 7670-7675.
  7. Paetzel, M., Dalbey, R. E. and Strynadka, N. C. J. (2002).  “Crystal Structure of a BacterialSignal Peptidase Apo-enzyme. J. Biol. Chem., 277, 9512-9519.
  8. Park, S-Y., Jiang, F., Dalbey, R. E. and Phillips, G. J. (2002). “Functional Analysis of the signal Recognition Particle in Escherichia coli a temperature-sensitive ffh Mutant.  J. Bacteriol., 184, 2642-2653.
  9. Jiang, F., Yi, L., Moore, M., Rohl, T., van Wijk, K-J., de Gier, J-W. L., Henry, R. and Dalbey, R. (2002). “Chloroplast YidC Homologue Albino3 can Functionally Complement the Bacterial YidC Depletion Strain and Promote Membrane Insertion of Both Bacterial and Chloroplast Thylakoid Proteins”, J. Biol. Chem., 277, 19281-19288.
  10. Dalbey, R. E. and von Heijne, G. (2002).  “Protein Targeting, Transport and Translocation”, Book, Academic Press.  [Dalbey, R. E. and von Heijen, G.  “Introduction and Overview”.  Pages 1-4; Dalbey, R. E., Chen, M., and Wiedmann, M.  “Methods in Protein Targeting, Translocation and and Transport” Pages 5-34; Dalbey, R. E. and von Heijne, G. “Conclusion and Perspective”.  Pages 402-406.]
  11. Chen, M., Xie, K., Jiang, F., and Dalbey, R. E. (2002). “YidC, a Newly Defined Evolutionarily Conserved Protein, Mediates Membrane Protein Assembly in Bacteria”.  Biol. Chem. 383, 1565-1572.
  12. Paetzel, M., Karla, A., Strynadka, N. C. J. and Dalbey, R. E. (2002).  “Signal Peptidases”.  Chem. Rev., 102, 4549-4580.
  13. Froderberg, L., Houben, E., Samuelson, J. C., Chen,M., Park, S-K., Phillips, G. J., Dalbey, R., Luirink, J. and de Gier, J-W. L. (2003) Versatility of inner membrane protein biogenesis in Escherichia coli.  Mol. Micro.  47, 1015-1027.
  14. Chen, M., Xie, K., Nouwen, N., Driessen, A. J. M. and Dalbey, R. E. (2003) Conditional lethal mutations separate the M13 Procoat and Pf3 Coat functions of YidC.  J. Biol. Chem., 278, 23295-23300.

74.  Yi, L., Jiang, F., Chen, M., Cain, B., Bolhuis, A., and Dalbey, R. E. (2003) YidC is strictly required for membrane insertion of subunit a and c of the F1FoATP synthase and SecE of the SecYEG Translocase.  Biochemistry, 42, 10537-10544.

75.  Kuhn, A., Stuart, R., Henry, R. and Dalbey, R. E. (2003) The Alb3/Oxa1/YidC protein family: membrane-localized chaperones facilitating membrane protein insertion?  Trends in Cell Biol., 13, 510-516.

76.  Jiang, F., Chen, M., Yi, L., de Gier, J-W., Kuhn, A., and Dalbey, R. E. (2003) Defining the regions of the Escherichia coli YidC that contribute to activity.  J. Biol. Chem. 278, 48965-48972.

77.  Serek, J., Bauer-Manz, G., Struhalla, G., van den Berg, L., Kiefer, D., Dalbey, R. E. and Kuhn , A. (2004).  Escherichia coli YidC is a membrane insertase for Sec-independent proteins.  EMBO J., 23, 294-301.

78.  Gerard, F., Pradel, N., Ye, C., Ize, B., Yi, L., Xu, J., Dalbey, R. E. and Wu, L-F. (2004). Putative membrane assembly of EtpM-Colicin V chimeras. Biochimie 86, 283-286.

79.  Paetzel, M., Goodall, J. J., Kania, M., Dalbey, R. E. and Page, M. G. P. (2004).  Crystallographic and biophysical analysis of a bacterial signal peptidase complex with a lipopeptide-based inhibitor.  J. Biol. Chem. 279, 30781-30790.

80.  Yi, L., Celebi, N., Chen, M. and Dalbey, R. E (2004).  Sec/SRP requirements and energetics of subunits a, b, and c of the Escherichia coli F1F0ATP Synthase.  J. Biol. Chem. 279, 39260-39267.

81.  Dalbey, R. E. and Kuhn, A. (2004).  YidC family members are involved in the membrane insertion, lateral integration, folding and assembly of membrane proteins.  J. Cell Biol., 166, 769-774.

82.  Dalbey, R. E. and Chen, M. (2004).  Sec-mediated membrane protein biogenesis.  Bioc. Biophys. Acta.,1694, 37-53.

83.  Paetzel, M. and Dalbey, R. E. (2005).  Membrane protein insertion in bacteria from a structural perspective, published in “protein movement across membranes, edited by Jerry Eichler, Landes Bioscience Publisher, 53-70.

84.  Karla, A., Lively, M.O., Paetzel, M. and Dalbey, R. E. (2005).  The identification of residues that control signal peptidase cleavage fidelity and substrate specificity, J. Biol. Chem. 280, 8, 6731-6741.

85.  Yi, L. and Dalbey, R. E. (2005).  Oxa1/Alb3/YidC system for insertion of membrane proteins in mitochondria, chloroplasts and bacteria.  Mol. Mem. Biol. 22, 10-111.

86.  Chen, M., Yuan, J., Yi, L. Xie, Facey, S. J., Pradel, N., L-F. Wu, Kuhn, A. and Dalbey, R. E.  (2005). Involvement of SecDF and the Sec related function of YidC in the membrane insertion of M13 Procoat mutants.  Biochemistry 44, 10741-10749.

87.  Celebi, N., Yi, L., Facey, S. J., Kuhn, A. and Dalbey, R. E. (2006).  Membrane protein biogenesis of subunit II of cytochrome bo oxidase: contrasting requirements for the insertion of N-terminal and C-terminal domains.  J. Mol. Biol. 357, 1428-1436

88.  Xie, K., Kiefer, D., Nagler, G., Dalbey, R. E. and Kuhn, A. (2006).  Different regions of the non-conserved large periplasmic region of Escherichia coli YidC are involved in SecF interaction and in membrane insertase activity.  Biochemistry, 45, 13401-13408.

89.  Doğan Ekici, Ö., Karla, A., Paetzel, M., Lively, M. O., Pei, D. and Dalbey, R. E. (2007).  Altered -3 substrate specificity of E. coli signal peptidase I mutants as revealed by screening a combinatorial peptide library.  J. Biol. Chem. 282, 417-425.

90.  Celebi, N. and Dalbey, R. E. (2007).  YidC- a protein with multiple functions in bacterial membrane biogenesis.  Pages 93-109; The Enzymes (vol. 25).  Molecular Machines involved in protein transport across cellular membranes; Editors.  R. E. Dalbey, C. Koehler, and F. Tamanoi.

91.  Yuan, J., Phillips, G. J. and Dalbey, R. E. (2007).  Isolation of Cold sensitive yidC Mutants Provide Insights into the Substate Profile of the YidC Insertase and the Importance of Transmembrane Three in YidC Function.  J. Bacteriol,  in press.

92.  Celebi, N. and Dalbey, R. E. (2008).  Mechanism and Hydrophobic Forces Driving Membrane Protein Insertion of Cytochrome BO Oxidase.  J. Mol. Biol., in press.

93.  Xie, K., Hessa, T., Seppala, S., Rapp, M., von Heijne, G. and Dalbey, R. E. (2008).  Features of Transmembrane Segments that Promote the Lateral Release From the Translocase into the Lipid Phase.  Biochemistry, in press.