The Chan Research Group 

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BIOGRAPHICAL SKETCH

 

NAME

POSITION TITLE

Michael K. Chan

Associate Professor

 

 

EDUCATION/TRAINING

 

INSTITUTION AND LOCATION

DEGREE

YEARS(S)

FIELD OF STUDY

Harvey Mudd College, Claremont, CA

B.S.

1982-1986

Chemistry

University of California, Berkeley, CA

Ph.D.

1986-1991

Chemistry

California Institute of Technology, Pasadena, CA

Postdoc

1991-1995

Protein Crystallography

 

 

RESEARCH AND PROFESSIONAL EXPERIENCE

 

Professional Positions:

 

1991-1995          Postdoctoral Research Associate, Department of Chemistry,

                        California Institute of Technology, Pasadena, CA

                        (Advisor: Dr. Douglas C. Rees)

 

1995-2001          Assistant Professor of Chemistry and Biochemistry,

                        The Ohio State University, Columbus, OH

 

2001-present       Associate Professor of Chemistry and Biochemistry,

                        The Ohio State University, Columbus, OH

 

                        OSU Interdisciplinary Affiliations

                    

                         • Ohio State University Biochemistry Program

                         • Ohio State University Biophysics Program

 

Honors

 

 • Lando-SOHIO Fellowship, University of Minnesota (1984)

 

 • Sigma Xi (1986)

 

 • Phi-Lambda Upsilon (1986)

 

 • Regents Fellowship, University of California  (1986)

 

 • Amoco Foundation Fellowship in Chemistry (1991)

 

 • NIH Postdoctoral Fellowship (1992-1994)

 

 • NSF Career Award (2000)

 

 • Alfred P. Sloan Fellowship (2000)

 

 • Adhoc, NIH Study Section - Physical Biochemistry (2001)

 

 • Adhoc, NIH Study Section - BMT (2001)

 

 • Member, NIH Study Section - BMT (2002-2006)

 

 • Mr and Mrs. Sun Chan Award in Organic Chemistry (2002)

 

 • Visiting Scholar of the National Research Council of the Republic of China (Academia Sinica, 2002)

 

 • OSU College of Biological Sciences Award for Research and Graduate Education (2004)

 

PUBLICATIONS

 

1.     Hao, B., Zhao, G., Kang, P.T., Soares, J.A., Ferguson, T.K., Gallucci, J., Krzycki, J.A., Chan, M.K., “Reactivity and chemical synthesis of L-pyrrolysine - the 22nd genetically-encoded amino acid”, Chem. Biol., 2004, 11, 1317-24.

 

2.     Blight, S.K.; Larue, R.C., Mahapatra, A., Longstaff, D.G., Chang, E. Zhao, G., Kang, P., Green-Church, K.B., Chan, M.K., Krzycki, J.A., “Direct charging of tRNACUA with pyrrolysine in vitro and in vivo”, Nature, 2004, 431, 333-5.

 

3.     Fekner, T., Gallucci, J, Chan., M.K., “Synthesis and metalation of a chiral, pyridine-strapped, cyclic bis(benzimidazole) ligand” Org. Lett., 2004, 6, 989-92. (Org. Lett., hot article)

 

4.     Fekner, T., Gallucci, J, Chan., M.K., “Ruffling-induced chirality: synthesis, metallation, and optical resolution of highly non-planar, cyclic benzimidazole-based ligands” J. Am. Chem.  Soc., 2004, 126, 223-36.

 

5.     Fekner, T., Gallucci, J, Chan., M.K., “Intramolecular aromatic nucleophilic substitution of the benzimidazole-activated nitro group” Org. Lett., 2003, 5, 4795-8.

 

6.     Zhong, X., Hao, B., Chan, M.K., “Structure of the PAS fold and signal transduction mechanisms” in PAS Proteins: Regulators and Sensors of Development and Physiology, Crews, S. Ed., 2003, Kluwer Publishing, New York, NY.

 

7.     Jain, R. Chan, M.K., “Mechanisms of ligand discrimination by heme proteins” JBIC, 2003, 8, 1-11.

 

8.     Hao, B., Gong, W., Ferguson, T.K., James, C.M., Krzycki, J.A., Chan, M.K., “Identification of novel UAG encoded residue: structure of a methanogen methyltransferase” Science, 2002, 296, 1462-1466. (C&E News, Nature, Science, CNN Headline News, Reuters)

 

9.     Hao, B., Isaza, C., Arndt, J., Soltis, M., Chan, M.K., "Structural analysis of the mechanism of oxygen sensing by the FixL heme domain of Bradyrhizobium japonicum" Biochemistry, 2002, 41, 12952-12958.

 

10.   Arndt, J.W., Hao, B., Ramakrishnan, V., Chen, T., Chan, S. I., Chan,, M.K., “Structure of the hyperthermophilic Pyrococcus furiosus carboxypeptidase” Structure, 2002, 10, 215-224.

 

11.   Payra, P. Hung, S.-C., Kwok, W.-H., Johnston, D. Gallucci, J., Chan, M.K., “Structural, Magnetic and Catalytic Properties of a Self-Recognized m-Oxo-Bridged Diiron(III) Bis(benzimidazole) Complex“, Inorg. Chem., 2001, 40, 4036-4039.

 

12.   Arndt, J.W., Gong, W., Zhong, X., Liu, J., Lin, Z., Schowalter, A.K., Paxson, C., Tsai, M.-D., Chan, M.K., “Insight into the Catalytic Mechanism of DNA Polymerase b: Structures of Intermediate Complexes”, Biochemistry, 2001, 40, 5368- 5375.

 

13.   Chan, M.K., “Recent advances in heme-protein biosensors”, Curr. Opin. Chem. Biol., 2001, 5, 216-222.

 

14.   Chan, M.K.“CooA,CAP and allostery”, Nat. Struct. Biology, 2000, 7, 822-824.

 

15.   Kwok, W.H., Zhang, H., Payra, P., Duan, M., Hung, S.-C., Johnston, D.H., Gallucci, J., Skrzypczak-Jankun, E., Chan, M.K., “Synthesis and characterization of the dimethyl-substituted bisbenzimidazole ligand and its manganese complex”, Inorg. Chem., 2000, 39, 2367-2376.

 

16.   Chan, M. K., “Symposium Overview: Heme Protein Biosensors”, J. Porphyrins. Phthalocyanines, 2000, 4, 358-361.

 

17.   Gong, W., Hao, B., Chan, M.K., “New mechanistic insights from structural studies of the oxygen-sensing domain of Bradyrhizobium japonicum FixL”, Biochemistry, 2000, 3955-3962.

 

18.   Payra, P., Kwok, W.H., Zhang, H., Payra, P., Duan, M., Gallucci, J., Chan, M.K. “Structural trends in first row transition-metal bisbenzimidazole complexes”, Inorg. Chem., 2000, 39, 1076-1080.

 

19.   Hao, B., Gong, W., Rajagopalan, P.T.R., Zhou, Y., Pei, D., Chan. M.K., “Structural basis for the design of antibiotics targeting peptide deformylase”, Biochemistry, 1999, 38, 4712-4719.

 

20.   Randall, D. W., Chan, M. K., Armstrong, W. H., and Britt, R. D., “Pulsed 1H and 55Mn ENDOR studies of dinuclear Mn(III)Mn(IV) model complexes”, Mol. Phys., 1998, 95, 1283-1294.

 

21.   Gong, W., Hao, B., Mansy, S.S., Gonzalez, G. Gilles-Gonzalez, M.A., Chan, M.K., “Structure of a biological oxygen sensor: a new mechanism for heme-driven signal transduction”, Proc. Natl. Acad. Sci. USA, 1998, 95, 15177-15182.

 

22.   Chan, M.K., Gong, W., Rajagopalan, P.T.R., Hao, B., Tsai, C.M., Pei, D., Crystal structure of the Escherichia coli peptide deformylase”, Biochemistry, 1997, 36, 13904-13909.

 

23.   Randall, D.W., Sturgeon,B.E., Ball,J.A., Lorigan,G.A., Chan, M.K., Klein,M.P.,  Armstrong,W.H., Britt, R.D., "Mn-55 ESE-ENDOR of a mixed-valence Mn(III)Mn(IV) complex - comparison with the Mn cluster of the photosynthetic oxygen-evolving complex", J. Am. Chem. Soc., 1995, 117, 11780-11789.

 

24.   Kletzin, A., Mukund, S., Kelleycrouse, T.L., Chan, M.K., Rees, D.C., Adams, M.W.W., "Molecular characterization of the genes encoding the tungsten-containing aldehyde ferredoxin oxidoreductase from Pyrococcus-furiosus and formaldehyde ferredoxin oxidoreductase from Thermococcus-litoralis", J. Bacteriology, 1995, 177, 4817-4819.

 

25.   Chan, M.K., Mukund, S., Kletzin, A., Adams, M.W.W., Rees, D.C., "The 2.3Å resolution structure of the tungstoprotein aldehyde ferredoxin oxidoreductase from the hyperthermophilic archaeon Pyrococcus furiosus", Science, 1995, 267, 1463-1469.

 

26.   Rees, D.C., Chan, M.K.;,Kim, J., “Structure and Function of Nitrogenase" in Advances in Inorganic  Chemistry,  Vol. 40.; A.G. Sykes Ed.; Academic Press, Inc., San Diego, California, 1994, p. 89.

 

27.   Chan, M.K., Kim, J., Rees, D.C., "The nitrogenase FeMo-cofactor and P-cluster pair: 2.2 Å resolution structures", Science, 1993, 260, 792-794.

 

28.   Rees, D.C., Kim, J., Georgiadis, M., Chan, M.K., Komiya, H., Woo, D., Chirino, A.J., Schlessman, J.,  Hsu, B.T., "Structures and Functions of the Nitrogenase Proteins" in  New Horizons in Nitrogen  Fixation; Palacios, R., Mora, J., Newton, W.E., Eds.; Kluwer Academic Publishers, Dordrecht, the  Netherlands, 1993, p. 83.    

 

29.   Rees, D.C., Kim,J., Georgiadis, M.M., Komiya, H., Chirino,A.J., Woo, D., Schlessman, J., Chan,  M.K., Joshua-Tor,L., Santillan, G., Chakrabarti, P., Hsu, B.T., "Crystal-Structures of the Iron Protein  and Molybdenum Iron Protein of Nitrogenase" in  Molybdenum Enzymes, Cofactors, and Model Systems,  ACS Symposium Series  535, Stiefel, E.I., Coucouvanis, D., Newton, W.E. Eds., American Chemical  Society, Washington D.C., 1993;  p. 170.

 

30.   Kirk, M.L., Chan, M.K., Armstrong, W.H., Solomon, E.I., "Ground-state electronic structure of the dimer-of-dimers complex [(Mn2O2)2(tphpn)2]4+: Potential relevance to the photosystem II water oxidation catalyst", J. Am. Chem. Soc., 1992, 114, 10432-10440.

 

31.   Pal, S.; Chan, M.K., Armstrong, W.H. "Ground spin state variability in manganese oxo aggregates.  Demonstration of an S=3/2 ground state for [Mn3O4(OH)(bpea)3] (ClO4)3”, J.  Am. Chem. Soc., 1992, 114, 6398-6406. 

 

32.   Cramer, S.P., deGroot, F.M.F., Ma, Y., Chen, C.T., Sette, F., Kipke, C.A., Eichhorn, D.M., Chan, M.K.., Armstrong, W.H., Libby, E., Christou, G., Brooker, S., McKee, V., Mullins, O.C.,  Fuggle, J.C.  "Ligand field strengths and oxidation states from manganese L-edge spectroscopy", J. Am. Chem.  Soc., 1991, 113, 7937. 

 

33.   Chan, M.K., Armstrong, W.H. “A tetranuclear manganese complex that consists of a di-alkoxo-bridged dimer of di-oxo-bridged dimers, [(Mn2O2)2(tphpn)2}4+. Toward a model for the water oxidation catalyst in photosystem II”, J. Am. Chem. Soc., 1991, 113, 5055-5057.

 

34.   Chan, M.K., Armstrong, W.H. " A tetranuclear manganese-oxo complex with a 2.7 Å Mn•••Mn separation and intramolecular H2O•••(m2-O) hydrogen-bonded contacts: [Mn4O2(TPHPN)2(H2O)2(CF3SO3)2](CF3SO3)3. Possible mode for binding of water at the active site of the oxygen-evolving complex in photosystem II" J. Am. Chem. Soc., 1990, 112, 4985-4986.

 

35.   Chan, M.K., Armstrong, W.H. " A novel tetranuclear manganese complex that displays multiple high-potential redox processes. Synthesis, structure, and properties of {[Mn2(TPHPN)(O2CCH3)2(H2O)]2O}(ClO4)4•2CH3OH" J. Am. Chem. Soc., 1989, 111, 9121-9122. 

 

36.   Dexheimer, S.L., Ghodes, J.W., Chan, M.K., Hagen, K.S., Armstrong, W.H., Klein, M.P. "Detection of EPR spectra in S=2 states of trivalent manganese complexes" J. Am. Chem. Soc., 1989, 111, 8923-8925.

 

37.   Chan, M.K., Armstrong, W.H. "A high-potential mononuclear manganese(IV) complex. Synthesis, structure, and properties, including EPR spectroscopy and electrochemistry, of [Mn(HB(3,5-Me2pz)3)2](ClO4)2" Inorg. Chem., 1989, 28, 3777-3779.

 

38.   Kubota, M.K., Chan, M.K., Boyd, D.C., Mann, K.R. "Thermal and photolytic reactions of nitrosyl-carbonyl complexes of rhodium and iridium with triphenylphosphine" Inorg. Chem., 1987, 26, 3261-3264.

 

39.   Kubota, M.K., Chan, M.K., Woo, L.K. "Iridium-Nitrogen bond cleavage in the photolysis of carbonylnitrosylbis(triphenylphosphine)iridium" Inorg. Chem., 1984, 23, 1636-1638.