Research
and Publications
My research, as a member of Kohler Group,
has focused on the photochemistry of DNA. In particular, I
have been focusing my efforts on how our understanding of the
photophysics - especially the lifetimes of excited states - can help
rationalize the rate and factors that govern the yield of DNA
photoproducts such as the thymine dimer.
- Theoretical Studies of Thymine
Dimer Formation
We have recently published
(Biophys. J., 2008 accepted)
a paper describing how a heuristic model can be used to
predict thymine dimer yields of dTpdT in various different
solvents, as well as the insight which can be obtained from such a
simple model on the (ultrafast) thymine dimer formation process.
Further research will focus on the theoretical basis for this
model and the extent to which this ground-state control paradigm as
well as the extent to which this can be applied to larger systems.
This
research has been featured
by the Ohio Supercomputer Centre at the Supercomputing '07
conference at Reno, NV. - Other interests
Other
interests include the extent to which, given the possibility of
self-repair in DNA, the extent to which the ground state paradigm is
applicable to the study of sequence and structural dependence of
thymine dimer yields in DNA.
Publications List
Peer-Reviewed Journal Articles
- Law,
Y. K., J. Azadi, C. E. Crespo-Hernandez, E. D. Olmon, and B. Kohler.
Prediction of thymine dimer quantum yields using molecular dynamics
simulations. Biophys. J. accepted. {BioFAST preprint]
Conference Abstracts
- Law,
Y. K., J. Azadi, and B. Kohler. 2007. Predicting DNA photodamage from
molecular dynamics simulations. In 9th Annual Midwest DNA Repair
Symposium, Columbus, OH. 37.
- Law, Y. K., J. Azadi, and B.
Kohler. 2007. Predicting thymine dimer formation from molecular
dynamics simulations. In 1st Annual Ohio State University Molecular
Life Sciences Interdisciplinary Graduate Programs Symposium, Columbus,
OH. 26..
Last updated 18 Jan, 2008v