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Nanoparticle Toxicity Research |
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Toxicity of respirable particles used in nanotechnology, such as carbon black (top), titanium dioxide (bottom right), and zeolite Y (bottom left,) are being investigated. Studies include phagocytosis by macrophages, inflammation and mutagenesis with the goal being the correlation of surface physicochemical properties with biological activity. This research is a collaboration between the Dutta, Waldman, Williams and Long groups.
Our research focuses on studying the surface
reactivity and biological activity of respirable particulates. Current
research goals include evaluation of mutagenic as well as
inflammatory effects of the particulates. Proteomic analysis of the cells is also
providing information on the different biological activities of the
particulates and is being correlated with surface structure and
composition.
There is currently a need for more information
about the physical and chemical properties of fine and ultrafine
particles during stages of their manufacture, and the implications of
those properties on the degree of toxicity of the particles. Such
information is necessary to establish reasonable industrial hygeine
practices in facilities where employees may be exposed to fine and
ultrafine particles.
| Group Member | Project | ||
| Brian Peebles | Physical and chemical basis of inflammation from nanoparticle exposure | Web page | |
| Amber Nagy | Quantifying inflammation in vitro from macrophage exposure to particles | Web page |
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